...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Induction of tumoricidal activity in mouse peritoneal macrophages by ginseng polysaccharide
【24h】

Induction of tumoricidal activity in mouse peritoneal macrophages by ginseng polysaccharide

机译：人参多糖诱导小鼠腹膜巨噬细胞杀伤活性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This study examined the effects of ginseng polysaccharide (GPS) on mouse peritoneal macrophage (PM)mediated cytotoxicity towards K562, HL-60. or KG1 alpha cells. GPS had no direct effect on killing of tumor cells However, when mouse PMs were treated with GPS, cytotoxic activity against K562, HL-60, or KG1 alpha cells was significantly induced In addition, phagocync activity was enhanced in GPS-treated mouse PMs compared to the control. The expressions of CD68. ACP and alpha-ANE in mouse PMs were Increased by the treatment with GPS. Moreover, the levels of cytokines, including tumor necrosis factor-alpha (TNF-alpha). interleukin-1 (IL-1). IL-6 were increased and the production of nitric oxide (NO) was enhanced Taken together, these results suggest that GPS possess a potent antitumor activity by stimulating macrophage and a potentiality as an immunomodulator against diseases such as cancer.
机译：这项研究检查了人参多糖（GPS）对小鼠腹膜巨噬细胞（PM）介导的对K562，HL-60的细胞毒性的作用。或KG1 alpha细胞。 GPS对杀死肿瘤细胞没有直接作用。但是，当用GPS处理小鼠PM时，会明显诱导出针对K562，HL-60或KG1α细胞的细胞毒活性。此外，与GPS处理的小鼠PM相比，吞噬活性增强了到控制。 CD68的表达。 GPS处理可增加小鼠PM中的ACP和α-ANE。此外，细胞因子的水平，包括肿瘤坏死因子-α（TNF-α）。白介素-1（IL-1）。总而言之，IL-6的增加和一氧化氮（NO）的产生得到了增强，这些结果表明GPS通过刺激巨噬细胞具有强大的抗肿瘤活性，并且具有作为抗癌剂的免疫调节剂的潜力。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号