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首页> 外文期刊>International journal of biomedical nanoscience and nanotechnology >Lactide-glycolide polymers as nano-dimensional carriers for drugs
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Lactide-glycolide polymers as nano-dimensional carriers for drugs

机译：丙交酯-乙交酯聚合物作为药物的纳米载体

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摘要

Biodegradable polymer poly (D, L-lactide-co-glycolide) as drug-carriers has been a preferred candidate in recent years for developing controlled/sustained release drug delivery systems especially of nano-dimensions due to the favourable physico-chemical characteristics and varieties available of the polymer. Efforts have been in progress to develop nanocarriers based on the polymer to maximise the bio-availability and efficacy of conventionalew extensively versatile drug molecules with minimum side-effects, provide pre-programmed drug release, prolonged duration of drug action and deliver drug at the site of action. This review describes recent work utilising biodegradable polymer poly (D, L-lactide-co-glycolide) for controlled drug dalivery, focusing on nanoparticulate delivery systems to shed lights on the present status and advancement of research on nanoformulations with this biodegradable synthetic polymer, mechanism of their cellular uptake and their safety concern. The review highlights the characteristics of the polymers in context to nanoparticles and updates the progress of research in the field in an abridged manner.
机译：由于具有良好的理化特性和品种，作为药物载体的生物可降解聚合物聚（D，L-丙交酯-乙交酯）作为药物载体，近年来已成为开发控制/持续释放药物递送系统（尤其是纳米尺寸）的首选药物。可利用的聚合物。正在努力开发基于聚合物的纳米载体，以最大程度地发挥具有最小副作用的常规/新型用途广泛的药物分子的生物利用度和功效，提供预编程的药物释放，延长的药物作用时间并在行动地点。这篇综述描述了利用可生物降解的聚合物聚（D，L-丙交酯-乙交酯）进行受控药物输送的最新工作，重点是纳米颗粒输送系统以阐明这种可生物降解的合成聚合物的纳米制剂的现状和研究进展，机理细胞摄取及其安全问题。该综述突出了纳米粒子背景下聚合物的特性，并以节略的方式更新了该领域的研究进展。

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