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首页> 外文期刊>British Journal of Obstetrics and Gynaecology >Urine albumin concentration and albumin-to-creatinine ratio at 11(+0) to 13(+6) weeks in the prediction of pre-eclampsia.
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Urine albumin concentration and albumin-to-creatinine ratio at 11(+0) to 13(+6) weeks in the prediction of pre-eclampsia.

机译：预测先兆子痫在11（+0）到13（+6）周时的尿白蛋白浓度和白蛋白/肌酐比值。

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OBJECTIVE: To determine the performance of screening for pre-eclampsia by maternal characteristics, urine albumin concentration and albumin-to-creatinine ratio (ACR) at 11(+0) to 13(+6) weeks. DESIGN: Prospective cross-sectional observational study. SETTING: Routine antenatal visit. POPULATION: A total of 2679 pregnant women at 11(+0) to 13(+6) weeks of gestation. METHODS: Maternal variables, urine albumin concentrations and ACR of 51 women who developed pre-eclampsia were compared with 2364 women who were unaffected by hypertensive disorders. Regression analysis was used first to determine which of the factors among the maternal characteristics were significant predictors of urine albumin concentration and ACR in the unaffected group and second to determine the contribution of urine albumin concentration and ACR in the prediction of pre-eclampsia. MAIN OUTCOME MEASURES: Development of pre-eclampsia. RESULTS: In the unaffected group, log urine albumin concentration and log ACR were influenced by ethnicorigin, age, body mass index (BMI), parity and smoking. In the prediction of pre-eclampsia, significant contributions were provided by log urine albumin concentration, log ACR, ethnic origin, BMI, age, family and history of pre-eclampsia. The median urine albumin concentration and the median ACR in the pre-eclampsia group were significantly higher than those in the unaffected group. However, in screening for pre-eclampsia, the area under the receiver operating characteristic curve was not significantly improved by the combined models than with maternal variables alone. The value of urine albumin concentration was not improved by correcting for the creatinine concentration. CONCLUSION: In the prediction of pre-eclampsia, urine albumin concentration at 11(+0) to 13(+6) weeks does not provide additional value to maternal variables.
机译：目的：通过母体特征，尿白蛋白浓度和白蛋白与肌酐比（ACR）在11（+0）至13（+6）周时确定子痫前期的筛查性能。设计：前瞻性横断面观察研究。地点：例行产前检查。人口：在怀孕11（+0）到13（+6）周时，共有2679名孕妇。方法：比较了51名先兆子痫妇女的母亲变量，尿白蛋白浓度和ACR与2364名未患高血压疾病的妇女的比较。回归分析首先用于确定母体特征中哪些因素是未患病组中尿白蛋白浓度和ACR的重要预测指标，其次用于确定尿白蛋白浓度和ACR在先兆子痫的预测中的作用。主要观察指标：先兆子痫的发展。结果：在未受影响的人群中，尿蛋白白蛋白的原浓度和ACR对数受种族起源，年龄，体重指数（BMI），胎次和吸烟的影响。在预测先兆子痫中，对数尿白蛋白浓度，对数ACR，族裔，BMI，年龄，家庭和先兆子痫病史提供了重要贡献。子痫前期组中位尿白蛋白浓度和中位ACR显着高于未受影响组。然而，在筛查先兆子痫时，与单独使用母体变量相比，组合模型并未明显改善接受者工作特征曲线下方的面积。通过校正肌酸酐浓度不能改善尿白蛋白浓度的值。结论：在预测先兆子痫时，尿白蛋白浓度在11（+0）到13（+6）周没有为母亲变量提供额外的价值。

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