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首页> 外文期刊>International journal of hyperthermia: The official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group >Effects of magnetic induction hyperthermia and radiotherapy alone or combined on a murine 4T1 metastatic breast cancer model.
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Effects of magnetic induction hyperthermia and radiotherapy alone or combined on a murine 4T1 metastatic breast cancer model.

机译：单独或联合使用磁感应热疗和放疗对小鼠4T1转移性乳腺癌模型的影响。

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PURPOSE: The purpose of this study was to explore the effects of MIH and radiotherapy alone or combined on metastatic breast cancer and the underlying mechanisms. MATERIALS AND METHODS: A murine 4T1 metastatic breast cancer model was established and randomly assigned into four treatment groups: C (control), R (radiotherapy), MIH, and MIH+R. Tumour volume, lung metastasis, the expression of Bax and MMP-9, T cell subsets, serum cytokine levels, and mouse survival were evaluated. RESULTS: Group MIH + R showed significantly reduced tumour volume, lung metastasis, improved survival and increased Bax expression compared to group R or MIH (P<0.05). MMP-9 expression in the primary tumour tissue was significantly increased in group R compared to the other groups (P<0.05), which could be brought down by combined MIH treatment. Group MIH +R showed significantly higher CD4(+) T cell percentage as well as CD4(+)/CD8(+) cell ratio than group R (P<0.05). Group MIH+R showed significantly higher serum levels of TNF-alpha, IFN-gamma and IL-2 than group R (P<0.05). CONCLUSIONS: MIH not only promotes the tumour-cell killing effect of radiotherapy through Bax-mediated cell death, but also improves cellular immunity in mice under radiotherapy and decreases the potential of radiotherapy to enhance MMP-9 expression, which leads to significant improvement in lung metastasis and overall survival of mice under combined treatment of MIH and R. This study is the first to have explored the effect of combined hyperthermia and radiotherapy on tumour metastasis and the underlying mechanisms. It provides insights into the application of MIH as an adjuvant to radiotherapy for metastatic breast cancer.
机译：目的：本研究的目的是探讨单独或联合使用MIH和放疗对转移性乳腺癌及其潜在机制的影响。材料与方法：建立了小鼠4T1转移性乳腺癌模型，并将其随机分为四个治疗组：C（对照组），R（放射治疗），MIH和MIH + R。评价肿瘤体积，肺转移，Bax和MMP-9的表达，T细胞亚群，血清细胞因子水平以及小鼠存活率。结果：与R或MIH组相比，MIH + R组显示出明显减少的肿瘤体积，肺转移，改善的生存率和Bax表达（P <0.05）。与其他组相比，R组中原发肿瘤组织中MMP-9的表达显着增加（P <0.05），这可以通过联合MIH治疗降低。 MIH + R组的CD4（+）T细胞百分比以及CD4（+）/ CD8（+）细胞比例明显高于R组（P <0.05）。 MIH + R组的血清TNF-α，IFN-γ和IL-2水平明显高于R组（P <0.05）。结论：MIH不仅通过Bax介导的细胞死亡增强了放射疗法对肿瘤细胞的杀伤作用，而且还提高了放射疗法小鼠的细胞免疫力，并降低了放射疗法增强MMP-9表达的潜力，从而显着改善了肺部MIH和R联合治疗对小鼠的转移和整体存活率的影响。这项研究是首次探索热疗和放疗联合治疗对肿瘤转移及其潜在机制的影响。它提供了关于MIH作为转移性乳腺癌放射治疗佐剂的应用的见解。

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