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首页> 外文期刊>International journal of immunopharmacology >Prophylactic effect of Korean mistletoe (Viscum album coloratum) extract on tumor metastasis is mediated by enhancement of NK cell activity.
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Prophylactic effect of Korean mistletoe (Viscum album coloratum) extract on tumor metastasis is mediated by enhancement of NK cell activity.

机译：韩国槲寄生提取物对肿瘤转移的预防作用是通过增强NK细胞活性来介导的。

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We here demonstrated the prophylactic effect of an extract (KM-110) from Viscum album coloratum, a Korean mistletoe, on tumor metastasis produced by highly metastatic tumor cells, colon 26-M3.1 carcinoma, B16-BL6 melanoma and L5178Y-ML25 lymphoma cells, using experimental models in mice. Intravenous (i.v.) administration of KM-110 (100 microg/mouse) 2 days before tumor inoculation significantly inhibited lung metastasis of B16-BL6 and colon 26-M3.1 cells, and liver and spleen metastasis of L5178Y-ML25 cells. The prophylactic effect of KM-110 on tumor metastasis was evident with various administration routes, i.e. subcutaneous, oral, intranasal as well as i.v., and was dependent upon the dose of KM-110 administered. Furthermore, mice given KM-110 (100 microg) 2 days before tumor inoculation showed significantly prolonged survival rates compared with the untreated mice. In a time course analysis of NK activity, i.v. administration of KM-110 (100 microg) significantly augmented NK cytotoxicity to Yac-a tumor cells from 1 to 3 days after KM-110 treatment. Furthermore, depletion NK cells by injection of rabbit anti-asialo GM1 serum completely abolished the inhibitory effect of KM-110 on lung metastasis of colon 26-M3.1 cells. These results suggest that KM-110 possesses immunopotentiating activity which enhances the host defense system against tumors, and that its prophylactic effect on tumor metastasis is mediated by NK cell activation.
机译：我们在这里证明了朝鲜槲寄生的Viscum album coloratum提取物（KM-110）对高转移性肿瘤细胞，结肠26-M3.1癌，B16-BL6黑色素瘤和L5178Y-ML25淋巴瘤产生的肿瘤转移的预防作用。细胞，使用小鼠实验模型。肿瘤接种前2天静脉（i.v.）施用KM-110（100微克/小鼠）可显着抑制B16-BL6和结肠26-M3.1细胞的肺转移以及L5178Y-ML25细胞的肝和脾转移。 KM-110对肿瘤转移的预防作用在各种给药途径，即皮下，口服，鼻内以及静脉内给药中是明显的，并且取决于所给药的KM-110的剂量。此外，与未治疗的小鼠相比，在肿瘤接种前2天给予KM-110（100微克）的小鼠显示出明显延长的存活率。在对NK活动的时程分析中， KM-110治疗后1到3天，施用KM-110（100微克）可以显着增强NK细胞对Yac-a肿瘤细胞的毒性。此外，通过注射兔抗亚洲GM1血清耗尽NK细胞完全消除了KM-110对结肠26-M3.1细胞肺转移的抑制作用。这些结果表明，KM-110具有增强宿主对肿瘤的防御系统的免疫增强活性，并且其对肿瘤转移的预防作用是由NK细胞激活介导的。

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