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首页> 外文期刊>International journal of immunopharmacology >Inhibitory effect of Asparagus cochinchinensis on tumor necrosis factor-alpha secretion from astrocytes.
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Inhibitory effect of Asparagus cochinchinensis on tumor necrosis factor-alpha secretion from astrocytes.

机译：芦笋对星形胶质细胞肿瘤坏死因子-α分泌的抑制作用。

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摘要

We investigated whether an aqueous extract of Asparagus cochinchinensis Merrill (Liliaceae) roots (ACAE) inhibits secretion of tumor necrosis factor-alpha (TNF-alpha) from primary cultures of mouse astrocytes. ACAE dose-dependently inhibited the TNF-alpha secretion by astrocytes stimulated with substance P (SP) and lipopolysaccharide (LPS). IL-1 has been shown to elevate TNF-alpha secretion from LPS-stimulated astrocytes while having no effect on astrocytes in the absence of LPS. We therefore investigated whether IL-1 mediated inhibition of TNF-alpha secretion from astrocytes by ACAE. Treatment of ACAE to astrocytes stimulated with both LPS and SP decreased IL-1 secretion. Moreover, incubation of astrocytes with IL-1 antibody abolished the synergistic cooperative effect of LPS and SP. These results suggest that ACAE may inhibit TNF-alpha secretion by inhibiting IL-1 secretion and that ACAE has a antiinflammatory activity in the central nervous system.
机译：我们调查了芦笋根的水提取物是否可以抑制小鼠星形胶质细胞原代培养物中肿瘤坏死因子-α（TNF-α）的分泌。 ACAE剂量依赖性地抑制了用物质P（SP）和脂多糖（LPS）刺激的星形胶质细胞的TNF-α分泌。已显示IL-1可提高LPS刺激的星形胶质细胞的TNF-α分泌，而在缺乏LPS的情况下对星形胶质细胞没有影响。因此，我们研究了ACAE是否通过IL-1介导星形胶质细胞抑制TNF-α分泌。用LPS和SP刺激星形胶质细胞治疗ACAE会降低IL-1分泌。此外，星形胶质细胞与IL-1抗体的孵育消除了LPS和SP的协同协同作用。这些结果表明ACAE可以通过抑制IL-1分泌来抑制TNF-α的分泌，并且ACAE在中枢神经系统中具有抗炎活性。

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