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首页> 外文期刊>International journal of immunogenetics >A discrepancy between serological and molecular typing results led to identification of a novel HLA-B*57 allele: HLA-B*5728N.
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A discrepancy between serological and molecular typing results led to identification of a novel HLA-B*57 allele: HLA-B*5728N.

机译:血清学和分子分型结果之间的差异导致鉴定出新的HLA-B * 57等位基因:HLA-B * 5728N。

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摘要

Summary Here, we describe the characterisation of a new allelic variant of HLA-B*57. The novel allele, HLA-B*5728N, was identified with sequence-based typing in a Caucasoid family. HLA-B*5728N, differs from HLA-B*5701 because of a nucleotide substitution at position 420 (C->G) resulting in a coding change from Tyrosine to a stop codon.
机译:总结在这里,我们描述了HLA-B * 57新等位基因变体的表征。新的等位基因HLA-B * 5728N在高加索家族中通过基于序列的分型鉴定。 HLA-B * 5728N与HLA-B * 5701不同,因为在位置420(C-> G)处的核苷酸取代导致从酪氨酸到终止密码子的编码变化。

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