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首页> 外文期刊>Biochemical Genetics >Identification of single nucleotide polymorphisms in the nicastrese goat and Sardinia Sheep mannose-binding lectin
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Identification of single nucleotide polymorphisms in the nicastrese goat and Sardinia Sheep mannose-binding lectin

机译：尼古斯特雷山羊和撒丁岛绵羊甘露糖结合凝集素单核苷酸多态性的鉴定

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摘要

This study was undertaken to detect polymorphisms in the goat and sheep mannose-binding lectin encoding gene (MBL2) and to explore allelic variability of this gene in these two species. The analysis and comparison of the sequences obtained from sheep showed 13 polymorphic sites, six in the promoter and seven in exon 1, four of which were of the missense type. In the goats, 12 polymorphic sites were detected, five intronic, five in the promoter, and one exonic. The exon site was responsible for an amino acid change. Mutations detected at the MBL2 locus in the sheep are of particular interest, being potentially responsible for the alterations of gene expression. A population survey involved 102 ewes of the Sardinian breed and 218 goats of the Nicastrese breed, all reared in southern Italy.
机译：进行这项研究以检测山羊和绵羊甘露糖结合凝集素编码基因（MBL2）的多态性，并探讨该基因在这两个物种中的等位基因变异性。从绵羊获得的序列的分析和比较显示出13个多态性位点，在启动子中有六个，在外显子1中有七个，其中四个是错义型。在山羊中，检测到12个多态性位点，五个内含子，五个启动子，一个外显子。外显子位点负责氨基酸的改变。在绵羊的MBL2基因座处检测到的突变特别令人感兴趣，这可能是基因表达改变的原因。一项人口调查涉及撒丁岛102头母羊和尼卡斯特雷斯（Nicastrese）品种218头山羊，全部在意大利南部饲养。

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