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首页> 外文期刊>International Journal of Radiation Biology: Covering the Physical, Chemical, Biological, and Medical Effects of Ionizing and Non-ionizing Radiations >Reasons to reconsider the significance of apoptosis for cancer therapy.
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Reasons to reconsider the significance of apoptosis for cancer therapy.

机译：重新考虑细胞凋亡对癌症治疗的重要性的原因。

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摘要

In recent years, the significance of apoptosis as a process in cell loss from normal tissue and tumours has been critically reviewed. In addition, the general lack of a correlation between radiation or drug-induced apoptosis and cell survival responses (using the clonogenic assay) in tumour cells has been demonstrated. Several different reasons have been discussed by other authors. It is the purpose of this review to argue that there are many different forms of cell death (terminal differentiation, micronucleation, mitotic catastrophe or multinucleation) that, like apoptosis, are regulated by the cell. In this context, apoptosis was the first cell death mechanism associated with active involvement of the cell (signal transduction). Furthermore, a large variety of different in vitro and a few in vivo models published so far show that the form of cell death can shift from, for example, mitotic catastrophe to apoptosis. The shift appears to be a general principle and depends on the cell model examined, the stressor type and the stressor intensity. These considerations help to explain the absence of a simple link between apoptosis and clonogenicity and suggest how to overcome that limitation, which has implications for the significance of apoptosis where the diagnosis and prognosis of cancer are concerned.
机译：近年来，已经对细胞凋亡作为正常组织和肿瘤细胞损失过程的重要性进行了严格的综述。此外，已证明肿瘤细胞中辐射或药物诱导的凋亡与细胞存活反应（使用克隆形成试验）之间通常缺乏相关性。其他作者已经讨论了几种不同的原因。这篇综述的目的是争论细胞凋亡有许多不同形式的细胞死亡（终末分化，微核，有丝分裂灾难或多核），它们由细胞调节。在这种情况下，细胞凋亡是与细胞主动参与（信号转导）相关的第一个细胞死亡机制。此外，迄今为止公开的多种不同的体外和几种体内模型表明，细胞死亡的形式可以从例如有丝分裂灾难转变为凋亡。这种转变似乎是一个一般原理，并取决于所检查的细胞模型，应激源类型和应激源强度。这些考虑有助于解释细胞凋亡与克隆形成性之间不存在简单的联系，并建议如何克服这一局限性，这在涉及癌症诊断和预后的细胞凋亡中具有重要意义。

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