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Quantitative assessment of injury in rat spinal cords in vivo by MRI of water diffusion tensor

机译：水扩散张量核磁共振成像对大鼠脊髓损伤的定量评估

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摘要

Magnetic resonance diffusion tensor imaging (DTI) of control and injured spinal cord of rats in vivo during first 6 h after the trauma was reported. DTI and histopathological results were compared. The aim of this work was to correlate the presence of damage of rat spinal cord with statistically significant changes in the apparent diffusion tensor components, in order to find the parameters that are useful in the visualization of the injury. Apparent diffusion tensor weighted data were measured in vivo 1 h after traumatic injury induced by a controlled weight drop on healthy and injured rat spinal cords for defined dozen regions of interest. Significant alternations in the injured regions of gray matter and white matter were detected. The differences in gray matter can be explained on the basis of cytotoxic edema due to ischemia and they are confirmed by the histological observations of neurons. The white matter changes in diffusional attributes are associated with the destruction of the nerve microstructure by the mechanical implant.
机译：据报道，在创伤后的头6 h内，大鼠的对照和受损脊髓的磁共振扩散张量成像（DTI）。比较DTI和组织病理学结果。这项工作的目的是将大鼠脊髓损伤的存在与表观扩散张量分量的统计学显着变化相关联，以便找到对损伤可视化有用的参数。表观扩散张量加权数据是在健康的和受伤的大鼠脊髓上受控制的体重下降引起的创伤性损伤后1 h内在体内确定的十几个感兴趣区域进行测量的。在受伤的灰质和白质区域检测到明显的交替。灰质的差异可以根据缺血引起的细胞毒性水肿进行解释，并由神经元的组织学观察证实。白质扩散属性的变化与机械植入物破坏神经微结构有关。

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