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首页> 外文期刊>British journal of neurosurgery >Pleomorphic xanthoastrocytoma: Long-term results of surgical treatment and analysis of prognostic factors
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Pleomorphic xanthoastrocytoma: Long-term results of surgical treatment and analysis of prognostic factors

机译：多形性黄体星形细胞瘤：手术治疗的长期结果和预后因素分析

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Background. Pleomorphic Xanthoastrocytoma (PXA) is a rare brain tumour, most commonly affecting children and young adults. To date, only few data regarding the long-term follow-up of these patients after surgery are available. The aim of this study is to describe our single-institution experience in the surgical management of this particular glioma over a period of over 18 years. Methods. We performed a retrospective review of all cases of PXA (40 patients) operated upon at the Department of Neurosurgery of Verona, Italy, between 1990 and 2008. The impact of clinical, radiological, surgical and histological factors on overall survival (OS) and progression-free survival (PFS) was analysed by means of univariate and multivariate models. Findings. We achieved a gross total resection (GTR) in 65% of patients. Histological diagnosis was of grade II in 80%; anaplastic features were present in the remaining 20%. Adjuvant treatment, radiotherapy or chemo-radiotherapy, was administered in 40% of the cases. Median follow-up was 74 months. OS at 5-and 10 years was 76.32% and 68.24%, respectively. PFS at 5-and 10 years was 71% and 58%, respectively. In the multivariate model, histological grade, extent of resection and age at diagnosis (≤ 30 years vs > 30 years) were the only independent prognostic factors for both OS and PFS. Conclusions. Our retrospective long-term study confirms the relatively favourable prognosis associated with PXA. Young patients with a low-grade tumour (WHO grade II) who underwent GTR carry the longest OS and PFS.
机译：背景。多形性黄体星形细胞瘤（PXA）是一种罕见的脑肿瘤，最常见于儿童和年轻人。迄今为止，关于这些患者术后长期随访的资料很少。这项研究的目的是描述我们超过18年的单机构在这种特殊神经胶质瘤的外科治疗中的经验。方法。我们对1990年至2008年在意大利维罗纳神经外科的所有PXA病例（40例）进行了回顾性回顾。临床，放射学，外科和组织学因素对总体生存（OS）和进展的影响通过单变量和多变量模型分析无生存期（PFS）。发现。我们在65％的患者中实现了总全切除（GTR）。组织学诊断为II级，占80％;在其余的20％中存在间变性特征。在40％的病例中进行了辅助治疗，放疗或化学放疗。中位随访时间为74个月。 5年和10年的OS分别为76.32％和68.24％。 5年和10年的PFS分别为71％和58％。在多变量模型中，组织学分级，切除范围和诊断时年龄（≤30岁vs> 30岁）是OS和PFS的唯一独立预后因素。结论我们的回顾性长期研究证实了与PXA相关的相对较好的预后。患有GTR的低度恶性肿瘤（WHO II级）的年轻患者携带最长的OS和PFS。

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