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首页> 外文期刊>Applied Magnetic Resonance >Characterization of Flow Distribution in the Blood Compartment of Hollow Fiber Hemodialyzers with Contrast-Enhanced Spin Echo Magnetic Resonance Imaging
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Characterization of Flow Distribution in the Blood Compartment of Hollow Fiber Hemodialyzers with Contrast-Enhanced Spin Echo Magnetic Resonance Imaging

机译：用对比增强自旋回波磁共振成像表征中空纤维血液透析仪血液室中的血流分布

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摘要

An optimized flow distribution is quintessential for hemodialyzers in order to maximize the mass transfer efficiency through the diffusion process. It is important to observe the flow pattern and the concentration profile within the hemodialyzer when evaluating its function. Thus experimental knowledge which can evaluate the above two parameters plays a significant part in the optimization of these modules. The objective of the present study was to propose an experimental method for evaluating the flow distribution pattern in the blood compartment of a hollow-fiber hemodialyzer using a contrast-enhanced spin echo T (1)-weighted magnetic resonance imaging (MRI) technique by tracing the concentration profiles and theoretical interpretation. Considering a parabolic flow profile inside the hollow fibers, the relative signal intensities along the axial direction of the five types of hemodialyzers were measured after injecting the Gd-DTPA contrast solution into the blood inlet. Although uniformly decreasing concentration profiles towards the outlet ports were observed during the analysis, the calculated mean and standard deviation (SD) of all average relative signal intensities indicated that there were variations in concentration distribution between the transverse sections of the same hemodialyzer. However, most of these variabilities were found to be within one SD of this mean value. These results suggested that the contrast-enhanced MRI technique can provide a significant tool for characterizing flow distribution in hemodialyzers, both qualitatively and quantitatively.
机译：对于血液透析器来说，优化的流量分配是最基本的，以使通过扩散过程的传质效率最大化。在评估其功能时，观察血液透析器内的流量模式和浓度分布很重要。因此，可以评估以上两个参数的实验知识在优化这些模块中起着重要的作用。本研究的目的是提出一种实验方法，通过使用对比增强的自旋回波T（1）加权磁共振成像（MRI）技术来评估中空纤维血液透析器血液室中的流量分布模式浓度分布和理论解释。考虑到中空纤维内部的抛物线流动轮廓，在将Gd-DTPA造影剂溶液注入血液入口后，测量了五种类型血液透析器沿轴向的相对信号强度。尽管在分析过程中观察到朝向出口的浓度分布均匀降低，但是所有平均相对信号强度的计算平均值和标准偏差（SD）表明，同一血液透析仪的横截面之间浓度分布存在变化。但是，发现大多数这些变异都在该平均值的一个SD之内。这些结果表明，对比增强的MRI技术可以为定性和定量地表征血液透析仪中的血流分布提供重要的工具。

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