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首页> 外文期刊>British journal of neurosurgery >Salvage therapy for recurrent germinomas in the central nervous system.
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Salvage therapy for recurrent germinomas in the central nervous system.

机译：打捞疗法用于中枢神经系统复发性生殖瘤。

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This report presents the results of salvage therapy for 15 recurrent germinomas. The first recurrence occurred at a median of 37 months (range 6-122 months) after primary therapy. By the median follow-up period of 57 months after the first recurrence, seven of the 15 patients had died of the recurrent disease. Eleven of 15 patients who had been treated with reirradiation once achieved a complete response. Of these 11 patients, six had a second recurrence and two developed disabling radiation necrosis. Six of the 15 patients received a platinum-based chemotherapy and they also achieved a complete response. However, the remissions after chemotherapy alone were not durable. Three of the six patients received an additional low-dose (20-24 Gy) of irradiation following the chemotherapy and remained tumour-free with a performance status of more than 70%. Overall, the recurrent germinomas were consistently responsive to salvage radiation therapy and chemotherapy. However, just reirradiation or platinum-based chemotherapy alone was not sufficient to prevent a further recurrence. A low-dose of radiation therapy following chemotherapy is therefore recommended.
机译：该报告介绍了15种复发性生殖瘤的挽救治疗结果。初次复发发生在初级治疗后的中位时间37个月（6-122个月）。到第一次复发后的57个月的中位随访期中，15例患者中有7例死于复发性疾病。 15例接受再放射治疗的患者中有11例完全缓解。在这11例患者中，有6例再次复发，其中2例发展为放射性坏死性坏死。 15例患者中有6例接受了铂类化疗，他们也获得了完全缓解。但是，仅化疗后的缓解并不持久。六名患者中的三名在化疗后接受了额外的低剂量（20-24 Gy）照射，并且保持无肿瘤状态，表现状态超过70％。总体而言，复发性生殖瘤对挽救性放疗和化疗始终如一。然而，仅再照射或仅基于铂的化学疗法不足以防止进一步复发。因此，建议在化疗后小剂量放疗。

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