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首页> 外文期刊>International medical journal: IMJ >Screening of Genetic Risk among Relatives and the General Public: Exploring the Spectrum of the Psychosis Prodrome
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Screening of Genetic Risk among Relatives and the General Public: Exploring the Spectrum of the Psychosis Prodrome

机译：亲戚和公众中遗传风险的筛查：探索精神病性谱线

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Objective: A large percentage of subjects with self-reported psychotic-like experiences (PLE) are found in the community and their status is unclear. The aim of the study is to detect the prevalence of non-affective psychosis and those with PLE among the relatives of patients with schizophrenia and the general public.Materials and methods: This was a two-stage procedure involving the first and second degree relatives of patients with schizophrenia and the general public. In the initial stage, the subjects were screened using a Screening Questionnaire (SQ). The positive subjects proceeded to the second stage and were assessed using the Comprehensive Assessment of At-Risk Mental State (CAARMS), the Global Assessment of Function (GAF), Hamilton Depression Rating Scale (HDRS) and Hamilton Anxiety Rating Scale (HARS).Results: A total of 660 subjects equally divided between the two groups formed a final sample. In the first stage, 170 (26%) subjects had positive scores on the SQ which was significantly higher in the general public. In the second stage, 34 (20%) cases were found to be positive, with a higher proportion among the relatives at genetic risk. The numbers of subjects with sub-threshold of attenuated psychotic symptoms (STAPS) (27%) and STAPS with affective symptoms (STAPSAS) (32%) detected was higher than those at Ultra High Risk (UHR) (23%) and non-affective psychosis (18%). Although no significant difference in the number of specific cases was detected between the general public and relatives at genetic risk, the proportion of relatives at genetic risk steadily increased as the illness progressed to full blown psychosis.Conclusions: Clinical assessment or re-interview following a self-report questionnaire is mandatory to detect individuals with psychotic disorders. The prevalence of subjects with elementary PLE (sub-threshold of APS) was higher than subjects with established psychotic symptoms such as UHR individuals. The prevalence of depression was high in pre-psychotic states before the psychotic symptoms became prominence. The contribution of genetic factors was more prominent as the illness progresses to frank psychosis.
机译：目的：在社区中发现大量具有自我报告的类似精神病经历（PLE）的受试者，其状态尚不清楚。本研究的目的是在精神分裂症患者和普通公众的亲属中检测非情感性精神病和PLE的患病率。材料和方法：这是一个分为两个阶段的过程，涉及一级和二级亲属。精神分裂症患者和普通大众。在初始阶段，使用筛查问卷（SQ）对受试者进行筛查。阳性受试者进入第二阶段，并使用风险心理状态综合评估（CAARMS），功能总体评估（GAF），汉密尔顿抑郁量表（HDRS）和汉密尔顿焦虑量表（HARS）进行评估。结果：共有660名受试者在两组之间平均分配，形成了最终样本。在第一阶段，有170名（26％）受试者的SQ得分为阳性，这在普通公众中明显更高。在第二阶段，发现34例（20％）阳性，有遗传风险的亲属比例更高。所检测到的亚精神状态缓解阈值（STAPS）（27％）和具有情感症状的阈值（STAPSAS）（32％）的受试者数高于超高风险（UHR）（23％）和非高危人群情感性精神病（18％）。尽管在普通公众和有遗传风险的亲属之间未发现具体病例数的显着差异，但随着疾病发展为完全精神病，有遗传风险的亲属比例稳步上升。自我报告调查表对于检测精神病患者是必不可少的。患有基本PLE（APS的亚阈值）的受试者的患病率高于具有确定的精神病症状的受试者（如UHR个人）。在精神病症状变得突出之前，精神病前状态的抑郁症患病率很高。随着疾病发展为坦率的精神病，遗传因素的贡献更加突出。

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