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首页> 外文期刊>British journal of neurosurgery >Single centre prospective study of the efficacy of percutaneous cement augmentation in the treatment of vertebral compression fractures
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Single centre prospective study of the efficacy of percutaneous cement augmentation in the treatment of vertebral compression fractures

机译：单中心前瞻性研究经皮水泥骨水泥治疗椎体压缩性骨折的疗效

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Introduction. Despite controversial outcomes of recent published trials, percutaneous cement augmentation remains widely used in managing painful vertebral compression fractures. We prospectively assessed patients with such fractures using an eleven-point visual analogue scale for pain and the Qualeffo 41 questionnaire for quality of life. Methods. Consecutive patients undergoing percutaneous cement augmentation for painful vertebral compression fractures were recruited. Patients were assessed pre-procedure by completing a visual analogue scale for pain, on a scale of 0 to 10. A Qualeffo 41 questionnaire was also completed. Patients were followed up at 1 week and 3 months. Results. Fifty six patients were prospectively recruited (111 vertebroplasty and 5 kyphoplasty). Visual analogue scores dropped from 6.4 ± 2.3 pre-procedure to 4.0 ± 2.7 at 1 week (p < 0.0001) and 4.3 ± 2.7 (p < 0.0001) at 3 months. Three subgroups were identified; osteoporotic patients (n = 28), a second non-osteoporotic group (n = 20) who had acute fracture following fall and a third group with compression fractures secondary to metastatic disease (n = 8). At 3-month follow-up, patients with osteoporotic fractures had reduction in pain score from 6.3 ± 2.1to 4.8 ± 2.7 (p = 0.02). Patients who had traumatic fractures experienced more significant pain relief, 6.4 ± 2.6 to 3.8 ± 2.7 (p = 0.0009) but patients with malignant fracture had most benefit, 6.0 ± 3.0 to 1.8 ± 0.8 (p = 0.01). Total Qualeffo scores improved from 63 ± 15 to 49 ± 22 (p < 0.0001). Within the domains of the Qualeffo questionnaire, most improvement was seen in pain and physical function. Median in-patient stay post procedure was one day. Conclusion. In our experience percutaneous cement augmentation is safe and efficacious in the management of painful VCF related to osteoporosis, trauma and cancer, achieving rapid and significant pain reduction and improvement in physical function as measured with a visual analogue scale and the Qualeffo 41 questionnaire.
机译：介绍。尽管最近发表的试验有争议的结果，但经皮水泥骨增强仍然广泛用于治疗疼痛的椎体压缩性骨折。我们使用十一点视觉模拟量表评估疼痛程度，并使用Qualeffo 41调查问卷评估生活质量，以评估此类骨折的患者。方法。招募了连续的患者，他们因疼痛的椎骨压缩性骨折而接受了经皮水泥骨增强术。术前通过完成疼痛的视觉模拟量表（范围为0到10）对患者进行评估。还完成了Qualeffo 41问卷。在第1周和第3个月对患者进行了随访。结果。前瞻性招募了56名患者（111椎骨成形术和5椎体后凸成形术）。视觉模拟评分从术前6.4±2.3降至1周时的4.0±2.7（p <0.0001）和3个月时4.3±2.7（p <0.0001）。确定了三个亚组。骨质疏松患者（n = 28），第二个非骨质疏松患者组（n = 20），其在跌倒后发生急性骨折，第三组患有继发于转移性疾病的压迫性骨折（n = 8）。在3个月的随访中，骨质疏松性骨折患者的疼痛评分从6.3±2.1降低到4.8±2.7（p = 0.02）。创伤性骨折患者的止痛效果更为显着，为6.4±2.6至3.8±2.7（p = 0.0009），而恶性骨折患者受益最大，为6.0±3.0至1.8±0.8（p = 0.01）。 Qualeffo的总得分从63±15提高到49±22（p <0.0001）。在Qualeffo调查表的范围内，疼痛和身体功能方面的改善最大。住院中位住院时间为一天。结论。根据我们的经验，经皮水泥固结术在治疗与骨质疏松症，创伤和癌症有关的疼痛性VCF方面是安全有效的，可通过视觉模拟量表和Qualeffo 41问卷进行测量，从而实现快速，显着的疼痛减轻和身体功能的改善。

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