• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International review of psychiatry >Dopamine-related frontostriatal abnormalities in obesity and binge-eating disorder: Emerging evidence for developmental psychopathology
【24h】

Dopamine-related frontostriatal abnormalities in obesity and binge-eating disorder: Emerging evidence for developmental psychopathology

机译：肥胖和暴饮暴食症中与多巴胺有关的前额叶异常：发育性精神病理学的新证据

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Obesity and binge-eating disorder (BED) frequently arise in adolescence, which is a critical developmental time period where self-regulatory processes are formed. Indeed, both obesity and BED are thought to arise partly due to deficits in self-regulatory processes (i.e. lack of inhibitory control to overeat or binge). Recent neuroimaging studies have implicated the frontal cortex, a brain region involved in regulating inhibitory-control, and the striatum, which is thought to be involved in food reward, satiety and pleasure, in mediating responses to food cues and feeding in normal-weight individuals as well as obese and BED subjects. Intriguingly, frontostriatal circuits have been observed to be preferentially modulated in obese adults and similar associations have been observed in obese/overweight adolescents. Furthermore, brain dopamine (DA) is selectively altered in striatum in obese relative to normal-weight individuals, and frontostriatal regions constitute a major component of DA circuitry. The aim of this review will be to present the main findings from neuroimaging studies in obese and BED adults and adolescents, as these relate to frontostriatal circuitry, and to emphasize the potential for using functional neuroimaging in both humans and animals with the scope of obtaining information on developmental and molecular contributions to obesity and BED.
机译：肥胖和暴饮暴食症（BED）经常在青春期出现，这是形成自我调节过程的关键发育时期。确实，肥胖和BED均被认为部分是由于自我调节过程的缺陷（即缺乏抑制饮食过量或暴饮暴食所致）。最近的神经影像学研究表明额叶皮层，大脑区域参与调节抑制控制以及纹状体被认为与食物奖励，饱腹感和愉悦有关，介导对体重正常的个体对食物线索的反应和喂养以及肥胖和BED受试者。有趣的是，已观察到肥胖成年人优先调节前额窦回路，并且在肥胖/超重青少年中观察到类似的关联。此外，相对于正常体重的个体，肥胖者的纹状体中的脑多巴胺（DA）有选择性地改变，并且额窦区构成DA电路的主要组成部分。这篇综述的目的是介绍在肥胖和BED成人和青少年中进行的神经影像学研究的主要发现，因为它们与前额窦回路有关，并强调在获得信息的范围内在人和动物中使用功能性神经影像学的潜力。对肥胖和BED的发育和分子贡献。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号