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首页> 外文期刊>International Journal of Zoology >Effects of Exogenous Corticosterone on Circulating Leukocytes of a Salamander (Ambystoma talpoideum) Unusually Abundant Eosinophils
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Effects of Exogenous Corticosterone on Circulating Leukocytes of a Salamander (Ambystoma talpoideum) Unusually Abundant Eosinophils

机译：外源皮质酮对a异常嗜酸性粒细胞循环白细胞的影响

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When animals become stressed, their levels of glucocorticoid hormones increase, causing white blood cells to move from tissues to circulation or vice versa. The primary alteration is an increase in the abundance of circulating neutrophils and a decrease in lymphocytes in circulation. A lesser-known effect is a decrease in the number of circulating eosinophils. Salamanders in the genus Ambystoma have unusually high numbers of circulating eosinophils, and as such, any effect of stress hormones on circulating leukocytes (especially eosinophils) of these species should be especially pronounced. We conducted an experiment to determine the effect of corticosterone administration on leukocyte counts (from blood smears) of A. talpoideum salamanders. Salamanders were captured and sampled as reference animals (n = 11), given a sham injection (n= 8), or injected with 0.1cc of a 100mug/mI, corticosterone solution (n = 28). After 24 hours, relative neutrophil counts were higher and relative lymphocyte counts lower, in the corticosterone group than the sham and control groups. Absolute counts showed that this effect was driven by a reduction in lymphocytes, since neutrophil counts were statistically similar across treatments. Importantly, relative and absolutenumbers of eosinophils decreased in the sham and corticosterone groups, confirming the sensitivity of this cell to stress in amphibians.
机译：当动物承受压力时，其糖皮质激素的水平会增加，导致白细胞从组织转移到循环系统，反之亦然。主要的改变是循环中性粒细胞数量的增加和循环中淋巴细胞的减少。鲜为人知的效果是循环中嗜酸性粒细胞数量的减少。 Ambystoma属中的具有异常大量的循环嗜酸性粒细胞，因此，应激激素对这些物种的循环白细胞（尤其是嗜酸性粒细胞）的任何作用都应特别明显。我们进行了一项实验，以确定皮质类固醇激素对talpoideum salamanders白细胞计数（来自血液涂片）的影响。捕获并作为参考动物（n = 11）取样，进行假注射（n = 8），或注射0.1cc的100mug / ml皮质酮溶液（n = 28）。皮质酮组24小时后，相对于假手术组和对照组，相对中性粒细胞计数较高，而相对淋巴细胞计数较低。绝对计数表明，这种作用是由淋巴细胞减少所驱动的，因为不同治疗之间的中性粒细胞计数在统计学上相似。重要的是，在假手术组和皮质酮组中，嗜酸性粒细胞的相对数量和绝对数量均降低，证实了该细胞对两栖动物应激的敏感性。

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