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Vancomycin resistance in ocular infections.

机译:万古霉素对眼部感染的抵抗力。

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摘要

Antibiotic resistance among ocular pathogens is increasing in parallel with the worldwide rise in systemic microbial resistance. Specifically, methicillin-resistant Staphylococcus aureus (MRSA) is becoming more prevalent in cases of ocular infection ~ and numerous studies have tracked the development of resistance in infectious ocular isolates to fiuoroquinolones.2' '5 Vancomycin is often used for the treatment of serious ocular infections, including endophthalmitis, infectious keratitis, and orbital cellulitis. Use of vancomycin continues to increase as resistance to other antimicrobials develops. Given the global emergence of vancomycin-resistant microbes, there is considerable potential for these organisms to develop as pathogens in ocular disease. Having alternative therapies to vancomycin which are quickly available will be essential. Here, we review vancomycin resistance in ocular infections and new antimicrobials for treatment of vancomycin-resistant infections.
机译:眼部病原体之间的抗生素耐药性与全球范围内系统微生物耐药性的上升同时增加。具体而言,耐甲氧西林的金黄色葡萄球菌(MRSA)在眼部感染中变得越来越普遍〜大量研究跟踪了传染性眼部分离株对氟喹诺酮类药物的耐药性。2''5万古霉素通常用于治疗严重眼部疾病感染,包括眼内炎,感染性角膜炎和眼眶蜂窝织炎。随着对其他​​抗菌素耐药性的发展,万古霉素的使用继续增加。鉴于在全球范围内出现耐万古霉素的微生物,这些生物有很大的潜力发展为眼部疾病的病原体。对于万古霉素而言,拥有迅速可用的替代疗法将至关重要。在这里,我们综述了眼部感染对万古霉素的耐药性以及对万古霉素耐药性感染的新型抗菌药物的治疗。

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