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Alpha-contingent EEG feedback reduces SPECT rCBF variability.

机译:Alpha-contingent脑电图反馈减少了SPECT rCBF的变异性。

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摘要

EEG feedback methods, which link the occurrence of alpha to the presentation of repeated visual stimuli, reduce the relative variability of subsequent, alpha-blocking event durations. The temporal association between electro-cortical field activation and regional cerebral blood flow (rCBF) led us to investigate whether the reduced variability of alpha-blocking durations with feedback is associated with a reduction in rCBF variability. Reduced variability in the rCBF response domain under EEG feedback control might have methodological implications for future brain-imaging studies. Visual stimuli were randomly presented to seven subjects, contingent upon the occurrence of alpha (alpha-contingent stimulation (ACS)) or alpha-blocking (not-alpha-blocking-contingent stimulation (NACS)) events. We employed a within-subjects design. rCBF was measured from multiple, cortical and sub-cortical regions. The primary dependent variables were the Mean, Standard Deviation and the ratio of Mean/Standard Deviation of: 1) the alpha-blocking response durations and 2) the temporally summated rCBF responses within the Visual Associative regions of interest (ROIs). Additional within-subjects rCBF measures were derived to quantify the variance-reducing effects of ACS across multiple, distributed areas of the brain. Both EEG and rCBF measures demonstrated decreased variability under ACS. This improved control was seen for localized as well as anatomically distributed rCBF measures.
机译:EEG反馈方法将alpha的出现与重复的视觉刺激的呈现联系起来,减少了后续alpha阻塞事件持续时间的相对变化。皮层电场激活与区域性脑血流量(rCBF)之间的时间关联使我们研究了阿尔法阻滞持续时间与反馈的降低的变异性是否与rCBF变异性的降低有关。在脑电图反馈控制下,rCBF反应域的变异性降低可能对未来的脑成像研究具有方法学意义。视情况将视刺激随机分配给七个对象,具体取决于发生alpha(alpha偶然刺激(ACS))或alpha阻断(非alpha阻断偶然刺激(NACS))事件。我们采用了主题内设计。从多个,皮层和皮层下区域测量rCBF。主要的因变量是均值,标准偏差和均值/标准偏差之比:1)alpha阻断反应持续时间; 2)视觉相关性感兴趣区域(ROI)内的rCBF瞬时求和。得出了其他受试者内部rCBF量度,以量化ACS在大脑多个分布区域的减少方差的作用。在ACS下,EEG和rCBF均显示变异性降低。对于局部以及解剖上分布的rCBF措施,可以看到这种改进的控制。

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