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首页> 外文期刊>Investigative radiology >Comparison of Gd(DTPA-BMA) (Omniscan) versus Gd(HP-DO3A) (ProHance) relative to gadolinium retention in human bone tissue by inductively coupled plasma mass spectroscopy.
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Comparison of Gd(DTPA-BMA) (Omniscan) versus Gd(HP-DO3A) (ProHance) relative to gadolinium retention in human bone tissue by inductively coupled plasma mass spectroscopy.

机译：通过电感耦合等离子体质谱法比较G（DTPA-BMA）（Omniscan）与G（HP-DO3A）（ProHance）相对于g在人骨组织中的保留。

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OBJECTIVE: The objective of this study was to determine the gadolinium (Gd) concentration remaining in human bone tissue after administration of standard clinical doses of 2 Gd-based contrast agents: ProHance and Omniscan. MATERIALS AND METHODS: After administration of 0.1 mmol/kg of Gd chelate to patients undergoing hip replacement surgery, bone specimens were collected and analyzed, and compared with an age-matched control population without a history of Gd chelate administration. Bone specimens were collected fresh, refrigerated, and subsequently frozen. After grinding and freeze-drying, tissue digestion was performed using Teflon bombs and concentrated nitric acid. A method for analysis of Gd in bone specimens was developed and validated using inductively coupled plasma mass spectroscopy (ICP-MS). RESULTS: Results were compared with a previous study using a different technique for analysis of the same tissue specimens. Tissue retention was 1.77+/-0.704 microg Gd/g bone (n=9) for Omniscan and 0.477+/-0.271 microg Gd/g bone (n=10) for ProHance measured by ICP-MS. These findings confirmed results from the previous ICP-AES study. CONCLUSION: Omniscan (Gd[DTPA-BMA]) left approximately 4 times (previous study 2.5 times) more Gd behind in bone than did ProHance (Gd[HP-DO3A]).
机译：目的：本研究的目的是确定在服用标准临床剂量的两种基于Gd的造影剂ProHance和Omniscan后，人体骨组织中残留的G（Gd）浓度。材料与方法：在对接受髋关节置换手术的患者施用0.1 mmol / kg的Gd螯合物后，收集并分析骨标本，并与没有Gd螯合史的年龄匹配对照组进行比较。新鲜，冷冻并随后冷冻收集骨标本。研磨并冷冻干燥后，使用特富龙炸弹和浓硝酸进行组织消化。开发了一种分析骨标本中Gd的方法，并使用电感耦合等离子体质谱（ICP-MS）进行了验证。结果：将结果与先前的研究进行了比较，使用不同的技术对相同的组织样本进行了分析。通过ICP-MS测量，Omniscan的组织保留为1.77 +/- 0.704 microg Gd / g骨骼（n = 9），ProHance的组织保留为0.477 +/- 0.271 microg Gd / g骨骼（n = 10）。这些发现证实了以前的ICP-AES研究的结果。结论：与ProHance（Gd [HP-DO3A]）相比，Omniscan（Gd [DTPA-BMA]）在骨骼中残留的Gd大约多4倍（以前的研究是2.5倍）。

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