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首页> 外文期刊>Investigative radiology >In vitro demonstration using 19F magnetic resonance to augment molecular imaging with paramagnetic perfluorocarbon nanoparticles at 1.5 Tesla.
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In vitro demonstration using 19F magnetic resonance to augment molecular imaging with paramagnetic perfluorocarbon nanoparticles at 1.5 Tesla.

机译：使用19F磁共振进行体外演示，以1.5特斯拉的顺磁性全氟化碳纳米粒子增强分子成像。

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摘要

OBJECTIVES: This study explored the use of F spectroscopy and imaging with targeted perfluorocarbon nanoparticles for the simultaneous identification of multiple bio-signatures at 1.5 T. MATERIALS AND METHODS: Two nanoparticle emulsions with perfluoro-15-crown-5-ether (CE) or perfluorooctylbromide (PFOB) cores were targeted in vitro to fibrin clot phantoms (n=12) in 4 progressive ratios using biotin-avidin interactions. The CE nanoparticles incorporated gadolinium. Fluorine images were acquired using steady-state gradient-echo techniques; spectra using volume-selective and nonselective sampling. RESULTS: On conventional T1-weighted imaging, clots with CE nanoparticles enhanced as expected, with intensity decreasing monotonically with CE concentration. All clots were visualized using wide bandwidth fluorine imaging, while restricted bandwidth excitation permitted independent imaging of CE or PFOB nanoparticles. Furthermore, F imaging and spectroscopy allowed visual and quantitative confirmation of relative perfluorocarbon nanoparticle distributions. CONCLUSIONS: F MRI/S molecular imaging of perfluorocarbon nanoparticles in vitro suggests that noninvasive phenotypic characterization of pathologic bio-signatures is feasible at clinical field strengths.
机译：目的：本研究探索了使用F光谱和靶向全氟化碳纳米颗粒成像同时鉴定1.5 T下的多种生物特征的方法。材料和方法：两种具有全氟15冠-5醚（CE）或使用生物素-亲和素相互作用，将全氟辛基溴化物（PFOB）核心以4种递进比率体外靶向纤维蛋白凝块体模（n = 12）。 CE纳米颗粒掺入了ium。使用稳态梯度回波技术获取氟图像;使用体积选择性和非选择性采样的质谱图。结果：在传统的T1加权成像中，带有CE纳米粒子的凝块如预期的那样增强，强度随CE浓度单调降低。所有凝块均使用宽带宽氟成像技术进行可视化，而受限带宽激发允许对CE或PFOB纳米粒子进行独立成像。此外，F成像和光谱学允许相对全氟化碳纳米颗粒分布的视觉和定量确认。结论：体外全氟化碳纳米粒子的F MRI / S分子成像表明，病理学生物特征的无创表型表征在临床领域是可行的。

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