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首页> 外文期刊>International journal of surgical pathology >Late Hepatic Metastasis From a Duodenal Gastrointestinal Stromal Tumor (29 Years After Surgery): Report of a Case and Review of the Literature
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Late Hepatic Metastasis From a Duodenal Gastrointestinal Stromal Tumor (29 Years After Surgery): Report of a Case and Review of the Literature

机译：十二指肠胃肠道间质瘤的晚期肝转移（手术后29年）：一例报告并文献复习

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Gastrointestinal stromal tumor (GIST) metastases are found most commonly in the liver, on average 16 to 38 months after resection of the primary tumor, even if some delayed hepatic metastases from GISTs have been described. We report a case of a man with a giant liver mass at computed tomography scan. In September 1984, the patient had undergone resection of a duodenal tumor, diagnosed as schwannoma. A liver biopsy revealed a neoplasm composed of epithelioid and spindled cells, immunohistochemically positive to c-kit and Dog-1. Reexamining the duodenal tumor resected in 1984, it was reclassified as GIST. Sequencing revealed the same mutation of the c-kit gene in both duodenal and hepatic lesions. To the best of our knowledge, this case represents the longest disease-free interval between a primary GIST and its metastasis. A brief review of the literature and an analysis of the potential prognostic role of particular c-kit mutations are also provided.
机译：胃肠道间质瘤（GIST）转移最常见于肝脏，平均在原发肿瘤切除后16到38个月，即使已描述了一些从GIST延迟的肝转移。我们在计算机断层扫描中报告了一例肝脏巨大肿块的人。 1984年9月，患者接受了十二指肠肿瘤切除术，诊断为神经鞘瘤。肝活检显示由上皮样细胞和纺锤状细胞组成的肿瘤，对c-kit和Dog-1免疫组织化学阳性。重新检查1984年切除的十二指肠肿瘤，将其重新分类为GIST。测序揭示了十二指肠和肝脏病变中c-kit基因的相同突变。据我们所知，此病例代表了原发性GIST与转移之间最长的无病间隔。还提供了简短的文献回顾，并分析了特定c-kit突变的潜在预后作用。

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