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首页> 外文期刊>Endocrinology >Oxytocin reverses ovariectomy-induced osteopenia and body fat gain
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Oxytocin reverses ovariectomy-induced osteopenia and body fat gain

机译：催产素逆转卵巢切除术引起的骨质减少和体内脂肪增加

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Osteoporosis and overweight/obesity constitute major worldwide public health burdens that are associated with aging. A high proportion of women develop osteoporosis and increased intraabdominal adiposity after menopause. which leads to bone fractures and metabolic disorders. There is no efficient treatment without major side effects for these 2 diseases. We previously showed that the administration of oxytocin (OT) normalizes ovariectomy-induced osteopenia and bone marrow adiposity in mice. Ovariectomized mice, used as an animal model mimicking menopause, were treated with OT or vehicle. Trabecular bone parameters and fat mass were analyzed using microcomputed tomography. Herein, we show that this effect on trabecular bone parameters was mediated through the restoration of osteoblast/osteoclast cross talk via the receptor activator of nuclear factor-κB ligand /osteoprotegerin axis. Moreover, the daily administration of OT normalized body weight and intraabdominal fat depots in ovariectomized mice. Intraabdominal fat mass is more sensitive to OT that sc fat depots, and this inhibitory effect is mediated through inhibition of adipocyte precursor's differentiation with a tendency to lower adipocyte size. OT treatment did not affect food intake, locomotors activity, or energy expenditure, but it did promote a shift in fuel utilization favoring lipid oxidation. In addition, the decrease in fat mass resulted from the inhibition of the adipose precursor's differentiation. Thus, OT constitutes an effective strategy for targeting osteopenia, overweight, and fat mass redistribution without any detrimental effects in a mouse model mimicking the menopause.
机译：骨质疏松症和超重/肥胖症是与衰老相关的全球主要公共卫生负担。绝经后，很大比例的妇女发展为骨质疏松症并增加腹内肥胖。导致骨折和代谢紊乱。对于这两种疾病，没有没有重大副作用的有效治疗方法。我们以前显示催产素（OT）的使用可使小鼠卵巢切除术诱发的骨质减少和骨髓脂肪正常化。将卵巢切除的小鼠用作模拟更年期的动物模型，用OT或赋形剂治疗。使用微计算机断层扫描分析小梁骨参数和脂肪量。在这里，我们表明对小梁骨参数的这种影响是通过经由核因子-κB配体/骨保护素轴的受体激活的成骨细胞/破骨细胞串扰的恢复介导的。此外，在卵巢切除的小鼠中，每天服用OT可使体重和腹内脂肪贮库恢复正常。腹内脂肪量对OT较敏感，因为OT较sc的脂肪库更为敏感，而这种抑制作用是通过抑制脂肪细胞前体的分化并降低脂肪细胞大小而介导的。 OT疗法不影响食物摄入，运动能力或能量消耗，但确实促进了燃料利用的转变，有利于脂质氧化。另外，脂肪量的减少是由于抑制了脂肪前体的分化。因此，在模拟更年期的小鼠模型中，OT构成了针对骨质减少，超重和脂肪量再分配的有效策略，而没有任何有害影响。

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