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首页> 外文期刊>Endocrinology >Maternal High-Fat Diet and Offspring Expression Levels of Vitamin K-Dependent Proteins
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Maternal High-Fat Diet and Offspring Expression Levels of Vitamin K-Dependent Proteins

机译：孕妇高脂饮食和维生素K依赖蛋白的后代表达水平

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Studies suggest that bone growth and development and susceptibility to vascular disease in later life are influenced by maternal nutrition during intrauterine and early postnatal life. There is evidence for a role of vitamin K-dependent proteins (VKDPs) including osteocalcin, matrix Gla protein, periostin, and growth-arrest specific-protein 6, in both bone and vascular development. We have examined whether there are alterations in these VKDPs in bone and vascular tissue from offspring of mothers subjected to a nutritional challenge: a high-fat diet during pregnancy and postnatally, using 6-week-old mouse offspring. Bone site-specific and sex-specific differences across femoral and vertebral bone in male and female offspring were observed. Overall a high-fat maternal diet and offspring diet exacerbated the bone changes observed. Sex-specific differences and tissue-specific differences were observed in VKDP levels in aorta tissue from high-fat diet-fed female offspring from high-fat diet-fed mothers displaying increased levels of Gas6 and Ggcx compared with those of female controls. In contrast, differences were seen in VKDP levels in femoral bone of female offspring with lower expression levels of Mgp in offspring of mothers fed a high-fat diet compared with those of controls. We observed a significant correlation in Mgp expression levels within the femur to measures of bone structure of the femur and vertebra, particularly in the male offspring cohort. In summary, the current study has highlighted the importance of maternal nutrition on offspring bone development and the correlation of VKDPs to bone structure.
机译：研究表明，子宫内和产后早期的孕产妇营养影响着骨骼的生长发育和对血管疾病的敏感性。有证据表明，维生素K依赖性蛋白（VKDP）包括骨钙蛋白，基质Gla蛋白，骨膜蛋白和生长抑制特异性蛋白6在骨骼和血管发育中均起作用。我们已经检查了遭受营养挑战的母亲后代的骨骼和血管组织中的这些VKDP是否存在变化：使用6周龄的小鼠后代在怀孕期间和出生后进行高脂饮食。在雄性和雌性后代中，观察到股骨和椎骨的骨部位特异性和性别特异性差异。总体而言，高脂孕妇饮食和后代饮食加剧了观察到的骨骼变化。高脂饮食喂养的母亲的高脂饮食喂养的雌性后代的主动脉组织中的VKDP水平观察到性别特异性差异和组织特异性差异，与女性对照相比，高脂饮食喂养的母亲的Gas6和Ggcx水平升高。相反，在高脂饮食的母亲的后代中，雌性后代的股骨中的VKDP水平存在差异，Mgp的表达水平低于对照组。我们观察到股骨内Mgp表达水平与股骨和椎骨的骨结构测量之间存在显着相关性，特别是在男性后代队列中。总而言之，当前的研究强调了母体营养对后代骨骼发育以及VKDP与骨骼结构的相关性的重要性。

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