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The critical role of androgens in prostate development.

机译:雄激素在前列腺发育中的关键作用。

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摘要

Androgens are involved in every aspect of prostate development, growth, and function from early in male embryogenesis to prostatic hyperplasia in aging men and dogs. Likewise, androgen deprivation at any phase of life causes a decrease in prostate cell number and DNA content. The process by which the circulating androgen testosterone is converted to dihydrotestosterone in the tissue and dihydrotestosterone in turn gains access to the nucleus where it regulates gene expression, largely via interaction with a receptor protein, is understood, but the downstream control mechanisms by which hormonal signals are translated into differentiation, growth, and function are being unraveled.
机译:从雄性胚发生的早期到衰老的人和狗的前列腺增生,雄激素参与前列腺发育,生长和功能的各个方面。同样,雄激素剥夺在生命的任何阶段都会导致前列腺细胞数量和DNA含量下降。循环中的雄激素睾丸激素在组织中转化为二氢睾丸激素的过程,而二氢睾丸激素进而进入细胞核,在很大程度上通过与受体蛋白的相互作用来调节基因表达,但是下游控制机制通过激素信号被分解为差异,成长和功能。

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