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How do glucocorticoids cause hypertension: role of nitric oxide deficiency, oxidative stress, and eicosanoids.

机译:糖皮质激素如何引起高血压:一氧化氮缺乏,氧化应激和类花生酸的作用。

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摘要

The exact mechanism by which glucocorticoid induces hypertension is unclear. Several mechanisms have been proposed, although there is evidence against the role of sodium and water retention as well as sympathetic nerve activation. This review highlights the role of nitric oxide-redox imbalance and their interactions with arachidonic acid metabolism in glucocorticoid-induced hypertension in humans and experimental animal models.
机译:糖皮质激素诱导高血压的确切机制尚不清楚。已经提出了几种机制,尽管有证据表明钠和水activation留以及交感神经活化作用不大。这篇评论强调了在人和实验动物模型中一氧化氮-氧化还原失衡的作用及其与花生四烯酸代谢的相互作用。

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