Androgens and breast cancer in men and women.

Dimitrakakis C

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Androgens and breast cancer in men and women.

机译：男性和女性的雄激素和乳腺癌。

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Abundant clinical evidence suggests that androgens normally inhibit mammary epithelial proliferation and breast growth. Clinical and nonhuman primate studies support the notion that androgens inhibit mammary proliferation and, thus, may protect from breast cancer. On the other hand, administration of conventional estrogen treatment suppresses endogenous androgens and may, thus, enhance estrogenic breast stimulation and possibly breast cancer risk. Addition of testosterone to the usual hormone therapy regimen may diminish the estrogen/progestin increase in breast cancer risk, but the impact of this combined use on mammary gland homeostasis still needs evaluation.

机译：大量的临床证据表明，雄激素通常会抑制乳腺上皮的增殖和乳房的生长。临床和非人类灵长类动物研究都支持雄激素抑制乳腺增生，因此可以预防乳腺癌的观点。另一方面，常规雌激素治疗的给药会抑制内源性雄激素，因此可能会增强雌激素对乳房的刺激，并可能增加患乳腺癌的风险。在通常的激素治疗方案中添加睾丸激素可能会减少雌激素/孕激素增加乳腺癌的风险，但是这种联合使用对乳腺体内稳态的影响仍需要评估。

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《Endocrinology and Metabolism Clinics of North America》 |2011年第3期|共16页
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Dimitrakakis C;
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中图分类内分泌腺疾病及代谢病;
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1. Androgen receptor expression and breast cancer survival in postmenopausal women. [J] . Hu R, Dawood S, Holmes MD, Clinical cancer research: an official journal of the American Association for Cancer Research . 2011,第7期

机译：绝经后妇女的雄激素受体表达和乳腺癌存活率。
2. The association of plasma androgen levels with breast, ovarian and endometrial cancer risk factors among postmenopausal women. [J] . Danforth KN, Eliassen AH, Tworoger S International Journal of Cancer =: Journal International du Cancer . 2010,第1期

机译：绝经后妇女血浆雄激素水平与乳腺癌，卵巢癌和子宫内膜癌的危险因素相关。
3. The association of plasma androgen levels with breast, ovarian and endometrial cancer risk factors among postmenopausal women. [J] . Danforth KN, Eliassen AH, Tworoger S International Journal of Cancer =: Journal International du Cancer . 2010,第1期

机译：绝经后妇女血浆雄激素水平与乳腺癌，卵巢癌和子宫内膜癌的危险因素相关。
4. ERK/MAPK Regulation of the Androgen Responsiveness of Breast Cancer Cells [C] . Diana G. Azzam, Jasmine W.T. Tay, Melissa A. Greeve, International Symposium on Hormonal Carcinogenesis . 2008

机译：ERK / MAPK调节乳腺癌细胞的雄激素反应性
5. Help-seeking behavior for breast cancer: The impact of a culturally-sensitive Breast Cancer Education Program with African American women. [D] . Austin-Valere, Christina. 2010

机译：乳腺癌的寻求帮助行为：具有文化敏感性的乳腺癌教育计划对非洲裔美国妇女的影响。
6. Breast cancer and hormonal supplements in postmenopausal women. Increase in risk of breast cancer is small. [O] . C. J. Mugglestone 1995

机译：绝经后妇女的乳腺癌和激素补充剂。患乳腺癌的风险很小。
7. Microsatellites in the estrogen receptor (ESR1, ESR2) and androgen receptor (AR) genes and breast cancer risk in African American and Nigerian women. [O] . Yonglan Zheng, Dezheng Huo, Jing Zhang, 2012

机译：雌激素受体（EsR1，EsR2）和雄激素受体（aR）基因中的微卫星和非洲裔美国人和尼日利亚妇女的乳腺癌风险。
8. Targeting Androgen Receptor in Breast Cancer: Enzalutamide as a Novel Breast Cancer Therapeutic. [R] . Elias, A. 2016

机译：针对乳腺癌中的雄激素受体：恩杂鲁胺作为一种新型乳腺癌治疗药物。

Androgens and breast cancer in men and women.

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