Update on Global Intervention Studies in Type 1 Diabetes

ChiangJ.L.; HallerM.J.; SchatzD.A.

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Update on Global Intervention Studies in Type 1 Diabetes

机译：1型糖尿病全球干预研究的最新进展

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Remarkable progress has been made in strategies to arrest pancreatic β-cell destruction in type 1 diabetes. Although knowledge of the disease has increased, a safe therapeutic intervention to reverse or prevent it remains elusive. The interaction of genes, immune system, and environment result in a complex disease process that has delayed hopes for a cure. Several well-designed prevention and intervention studies have aspired to test potentially efficacious and safe therapies. This article updates the principles used to design prevention and intervention trials, reviews clinical trials, addresses controversial issues, and provides a framework for future efforts to interdict this condition.

机译：在遏制1型糖尿病中胰岛β细胞破坏的策略上已经取得了显着进展。尽管对这种疾病的了解有所增加，但要逆转或预防这种疾病的安全治疗干预措施仍然难以捉摸。基因，免疫系统和环境的相互作用导致了一个复杂的疾病过程，从而延缓了治愈的希望。数个设计周密的预防和干预研究旨在测试潜在有效和安全的疗法。本文更新了用于设计预防和干预试验的原则，回顾了临床试验，解决了有争议的问题，并为以后的努力制止这种情况提供了框架。

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《Endocrinology and Metabolism Clinics of North America》 |2012年第4期|共18页
作者
ChiangJ.L.; HallerM.J.; SchatzD.A.;
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正文语种 eng
中图分类内分泌腺疾病及代谢病;
关键词
Combination therapy; Intervention; Prevention; Type 1 diabetes;

机译：联合疗法;干预;预防;1型糖尿病;

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专利

1. Update on Global Intervention Studies in Type 1 Diabetes [J] . ChiangJ.L., HallerM.J., SchatzD.A. Endocrinology and Metabolism Clinics of North America . 2012,第4期

机译：1型糖尿病全球干预研究的最新进展
2. Study Protocol: The Norfolk Diabetes Prevention Study [NDPS]: a 46?month multi - centre, randomised, controlled parallel group trial of a lifestyle intervention [with or without additional support from lay lifestyle mentors with Type 2 diabetes] to prevent transition to Type 2 diabetes in high risk groups with non - diabetic hyperglycaemia, or impaired fasting glucose [J] . Melanie Pascale, Nikki Murray, Max Bachmann, BMC Public Health . 2017,第1期

机译：研究方案：诺福克糖尿病预防研究[NDPS]：一项为期46个月的多中心，随机，对照平行分组的生活方式干预试验[有无2型糖尿病的非专业生活方式指导者提供额外的支持]，以预防向2型糖尿病的过渡非糖尿病高血糖或空腹血糖受损的高危人群中有2位糖尿病
3. Risk Factor Modeling for Cardiovascular Disease in Type 1 Diabetes in the Pittsburgh Epidemiology of Diabetes Complications (EDC) Study: A Comparison With the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study (DCCT/EDIC) [J] . Rachel G. Miller, Tina Costacou, Trevor J. Orchard Diabetes . 2019,第2期

机译：匹兹堡糖尿病并发症流行病学（EDC）研究中1型糖尿病心血管疾病的危险因素建模：与糖尿病控制和并发症的比较糖尿病干预和并发症研究/流行病学研究（DCCT / EDIC）
4. Randomised Controlled Trial of an In-Home Monitoring Intervention to Improve Health Outcomes for Type 2 Diabetes: Study Protocol [C] . Karen CARLISLE, Robin WARREN, Paul SCUFFHAM, Global Telehealth (Conference) . 2012

机译：随机对照试验的内部监测干预以改善2型糖尿病的健康结果：研究方案
5. A pilot study of key components of a community-based, lifestyle intervention for middle school students who are "at-risk" for type 2 diabetes. [D] . Hilliard, Olivia Suzanne. 2009

机译：对处于“危险中”的2型糖尿病中学生的社区生活方式干预的关键组成部分的初步研究。
6. Comment on Cefalu et al. Update and Next Steps for Real-World Translation of Interventions for Type 2 Diabetes Prevention: Reflections From a Diabetes Care Editors’ Expert Forum. Diabetes Care 2016;39:1186–1201 [O] . W. Timothy Garvey 2017

机译：评论Cefalu等。对2型糖尿病预防干预的真实翻译的最新动态和下一步：糖尿病护理编辑专家论坛的思考。 2016年糖尿病护理； 39：1186–1201
7. Update and Next Steps for Real-World Translation of Interventions for Type 2 Diabetes Prevention: Reflections From a Diabetes Care Editors' Expert Forum. Diabetes Care 2016; 39: 1186-1201 [O] . Cefalu, William T., Buse, John B., Tuomilehto, Jaakko, 2017

机译：2型糖尿病预防干预的真实翻译的更新和后续步骤：来自糖尿病护理编辑专家论坛的反思。 2016年糖尿病护理; 39：1186-1201

Update on Global Intervention Studies in Type 1 Diabetes

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