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A nanocomposite chitosan based on ferrocene-modified silica nanoparticles and carbon nanotubes for biosensor application

机译：基于二茂铁改性的二氧化硅纳米颗粒和碳纳米管的纳米复合壳聚糖在生物传感器中的应用

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摘要

A novel amperometric biosensor for glucose was developed by entrapping glucose oxidase (GOD) in a chitosan composite doped with ferrocene monocarboxylic acid-aminated silica nanoparticles conjugate (FMC-ASNPs) and multiwall carbon nanotubes (MWNTs). The entrapped FMC-ASNPs conjugate performed excellent redox electrochemistry and the presence of MWNTs improved the conductivity of the composite film. Ibis matrix showed a biocompatible microenvironment for retaining the native activity of the entrapped GOD and was in favor of the accessibility of substrate to the active site of GOD, thus the affinity to substrates is improved greatly. Under optimal conditions this biosensor was able to detect glucose with a detection limit of 10 mu M (S/N = 3) in the linear range of 0.04 to 6.5 mM. The proximity of these three components FMC-ASNPs, MWNTs and GOD enhanced the electron transfer between the film and electrode. This composite film can be extended to immobilize other enzymes and biomolecules, which will greatly facilitate the development of biosensors and other bioelectrochemical devices.
机译：通过将葡萄糖氧化酶（GOD）包裹在掺杂有二茂铁单羧酸胺化的二氧化硅纳米颗粒共轭物（FMC-ASNPs）和多壁碳纳米管（MWNTs）的壳聚糖复合物中，开发了一种新型的葡萄糖生物传感器。截留的FMC-ASNPs共轭物具有出色的氧化还原电化学性能，MWNTs的存在改善了复合膜的导电性。 Ibis基质表现出生物相容性的微环境，可以保留被捕获的GOD的天然活性，并且有利于底物接近GOD活性位点，因此对底物的亲和力得到了极大的提高。在最佳条件下，该生物传感器能够以0.04至6.5 mM的线性范围内的10μM（S / N = 3）的检测限检测葡萄糖。这三个组分FMC-ASNP，MWNT和GOD的接近增强了薄膜与电极之间的电子转移。这种复合膜可以扩展以固定其他酶和生物分子，这将大大促进生物传感器和其他生物电化学装置的发展。

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