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Voltammetric determination of alpha-tocopheryl acetate in pharmaceutical dosage forms

机译：伏安法测定药物剂型中的乙酸α-生育酚酯

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摘要

A simple and rapid voltammetric method has been developed for the quantitative determination of alpha-tocopheryl acetate (alpha-TOAc) in pharmaceutical preparations. Studies with linear scan (LSV), square-wave (SQWV) and differential pulse voltammetry (DPV) were carried out using platinum microelectrodes. A well-defined, irreversible oxidation wave/peak was obtained at 1.30 V (vs. Ag/AgCl reference electrode.) The use of SQWV or DPV technique provides a precise determination of alpha-tocopheryl acetate using the multiple standard addition method. The statistical parameters and the recovery study data clearly indicate good reproducibility and accuracy of the method. Accuracy of the results assessed by recovery trials was found within the 99.3% to 103.5%, and 99.1% to 101.4%, for SQWV and DPV, respectively. The quantification limits for the both voltammetric techniques were found to be 6 x 10(-5) M (SQWV) and 7 x 10-5 M (DPV). Analysis of the authentic samples containing alpha-TOAc showed no interference with common additives and excipients, such as unsaturated fatty acids (co-formulated as glycerine esters) and vitamin A (as retinol or beta-carotene). The method proposed does not require any pretreatment of the pharmaceutical dosage forms. A gas chromatography determination of alpha-TOAc in real samples was also performed for comparison.
机译：已开发出一种简单而快速的伏安法，用于定量测定药物制剂中的乙酸α-生育酚酯（α-TOAc）。使用铂微电极进行了线性扫描（LSV），方波（SQWV）和差分脉冲伏安法（DPV）的研究。在1.30 V（vs。Ag / AgCl参比电极）处获得了明确的，不可逆的氧化波/峰值。使用SQWV或DPV技术可使用多种标准添加方法精确测定乙酸α-生育酚乙酸酯。统计参数和回收率研究数据清楚表明该方法具有良好的重现性和准确性。 SQWV和DPV的恢复试验评估结果的准确性分别在99.3％至103.5％和99.1％至101.4％之内。两种伏安技术的定量限分别为6 x 10（-5）M（SQWV）和7 x 10-5 M（DPV）。对包含α-TOAc的真实样品的分析显示，不干扰常见的添加剂和赋形剂，例如不饱和脂肪酸（共配制为甘油酯）和维生素A（视黄醇或β-胡萝卜素）。所提出的方法不需要药物剂型的任何预处理。还进行了气相色谱法测定真实样品中的α-TOAc进行比较。

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