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Potential role of tocotrienols in the treatment and prevention of breast cancer

机译：生育三烯酚在乳腺癌的治疗和预防中的潜在作用

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Vitamin E is a generic term that refers to a family of compounds that is further divided into two subgroups called tocopherols and tocotrienols. Although all natural forms of vitamin E display potent antioxidant activity, tocotrienols are significantly more potent than tocopherols in inhibiting tumor cell growth and viability, and anticancer activity of tocotrienols is mediated independently of their antioxidant activity. In addition, the anticancer effects of tocotrienols are observed using treatment doses that have little or no effect on normal cell function or viability. This review will summarize experimental studies that have identified the intracellular mechanism mediating the anticancer effects of tocotrienols. Evidence is also provided showing that combined treatment of tocotrienol with other cancer chemotherapies can result in a synergistic inhibition in cancer cell growth and viability. Taken together, these findings strongly indicate that tocotrienols may provide significant health benefits in the prevention and/or treatment of cancer when used either alone as monotherapy or in combination with other anticancer agents.
机译：维生素E是一个通用术语，是指一类化合物，可进一步分为两个子类，称为生育酚和生育三烯酚。尽管所有天然形式的维生素E均显示有效的抗氧化活性，但生育三烯酚在抑制肿瘤细胞生长和生存能力方面比生育酚显着更有效，并且生育三烯酚的抗癌活性不受其抗氧化活性的影响。另外，使用对正常细胞功能或生存力几乎没有或没有影响的治疗剂量观察到生育三烯酚的抗癌作用。这篇综述将总结已经确定介导生育三烯酚的抗癌作用的细胞内机制的实验研究。还提供了证据表明生育三烯酚与其他癌症化学疗法的联合治疗可导致癌细胞生长和生存力的协同抑制。综上所述，这些发现强烈表明，生育三烯酚单独或作为单一疗法或与其他抗癌药联合使用时，在预防和/或治疗癌症方面可提供重大的健康益处。

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