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首页> 外文期刊>Epigenetics: official journal of the DNA Methylation Society >Histone lysine methylation in genomic imprinting.
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Histone lysine methylation in genomic imprinting.

机译:基因组印迹中的组蛋白赖氨酸甲基化。

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摘要

Genomic imprinting is an epigenetic phenomenon that causes parent-of-origin-specific expression of a small subset of genes in mammals. DNA methylation is believed to be the primary epigenetic signal that controls genomic imprinting. These methylation imprints are established during gametogenesis in male and female germ cells and maintained and interpreted during embryogenesis and in somatic tissues. Based on recent studies, histone lysine methylation plays an important role in the regulation of imprinted gene expression and, more intriguingly, may also be involved in the establishment and maintenance of DNA methylation imprints. In this point of view, we discuss these studies and their implications.
机译:基因组印记是一种表观遗传现象,会导致哺乳动物中一小部分基因的原产地特异性表达。 DNA甲基化被认为是控制基因组印迹的主要表观遗传信号。这些甲基化印记在配子发生期间在雄性和雌性生殖细胞中建立,并在胚胎发生和体细胞组织中得以维持和解释。基于最近的研究,组蛋白赖氨酸甲基化在印迹基因表达的调节中起着重要作用,而且更有趣的是,它也可能参与DNA甲基化印迹的建立和维持。以这种观点,我们讨论这些研究及其含义。

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