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Primary mucoepidermold carcinoma of the esophagus:- review of the literature

机译：食管原发性粘液表皮样癌：-文献综述

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摘要

Mucoepidermoid carcinoma of the esophagus (MECE) is an unusual variant of esophageal cancer composed of a mixture of mucus-secreting adenocarcinoma and squamous cell carcinoma. Its pathological interpretation and nomenclature have altered, and even at the present time, two different theories to account for its histological origin can be considered. Previous reports have indicated that MECE shows aggressive biological behavior and has a poor prognosis. However, because of its rarity, the clinicopathological features have not been fully investigated. We collected 125 reported cases of MECE and analyzed their features. The median patient age was 62 years (range 40-92 years) and a male predominance was noted with a male:female ratio of 3.2:1. MECE preferentially occurs in the middle part of the thoracic esophagus. Lymph node metastasis was present in 53.8 % of advanced (T2-4) cases and 21.4 % of Tl cases. The outcome of MECE appears to have improved significantly during the past two decades (P < 0.01). However, survival period did not differ between patients undergoing surgery alone in = 65) and those receiving additional chemo/radiotherapy (n = 28, P = 0.43). Cox multivariate regression analysis revealed that the presence of lymph node metastasis (P < 0.01) and male gender (P = 0.01) were independent factors negatively impacting survival.
机译：食道粘液表皮样癌（MECE）是食管癌的一种不常见变体，由分泌粘液的腺癌和鳞状细胞癌的混合物组成。它的病理学解释和术语已经改变，甚至在目前，可以考虑两种不同的理论来解释其组织学起源。先前的报道表明，MECE具有侵袭性的生物学行为，预后差。但是，由于其稀有性，尚未对其临床病理特征进行充分研究。我们收集了125例报告的MECE病例并分析了它们的特征。患者的中位年龄为62岁（40-92岁），男性占优势，男性与女性的比例为3.2：1。 MECE优先发生在胸腔食道的中部。晚期（T2-4）病例中有53.8％和T1病例中有21.4％存在淋巴结转移。在过去的二十年中，MECE的结果似乎有了显着改善（P <0.01）。但是，仅接受手术的患者和接受其他化学/放射治疗的患者（n = 28，P = 0.43）的生存期没有差异。 Cox多元回归分析显示，淋巴结转移（P <0.01）和男性（P = 0.01）的存在是对生存产生负面影响的独立因素。

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