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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Pain in amyotrophic lateral sclerosis: A population-based controlled study
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Pain in amyotrophic lateral sclerosis: A population-based controlled study

机译：肌萎缩性侧索硬化症的疼痛：基于人群的对照研究

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Background and purpose: To assess the prevalence and characteristics of pain in an epidemiological series of patients with amyotrophic lateral sclerosis (ALS) compared to population-based controls. Methods: Of the 183 patients with ALS resident in the province of Torino, Italy, 160 accepted to be interviewed. Controls were randomly selected from the lists of general practitioners. Pain was assessed using the Brief Pain Inventory. Results: Patients with ALS reported pain more frequently than controls [91 (56.9%) vs. 53 (33.1%); P=0.001]. Pain frequency and intensity were correlated with a worse functional score and a longer disease duration. In patients with ALS, pain was more frequently located at the extremities (P=0.006). Pain interfered with all areas of daily function, but patients reported a greater interference than controls in the domains of enjoyment of life and relation with other people. Sixty-four patients (70.3% of those with pain) and 24 controls (45.3% of those with pain) (P=0.003) were treated for pain, most frequently with non-steroidal anti-inflammatory drugs. ALS cases were also more frequently prescribed non-opioid analgesics and opioids than controls. Conclusions: Our study indicates that pain is frequent in all stages of ALS, but that it often goes underrecognized and undertreated. It is significantly more frequent in patients with ALS than in population-based controls. Future studies need to clarify the mechanisms of pain in ALS and determine the most effective treatment strategy.
机译：背景与目的：与基于人群的对照相比，评估肌萎缩性侧索硬化症（ALS）流行病学系列患者的疼痛患病率和特征。方法：在意大利都灵省的183名ALS患者中，有160名接受了访谈。从全科医生名单中随机选择对照。使用简短疼痛清单评估疼痛。结果：ALS患者的疼痛报告频率高于对照组[91（56.9％）vs. 53（33.1％）; P ＝ 0.001]。疼痛频率和强度与较差的功能评分和更长的疾病持续时间相关。在ALS患者中，疼痛更常发生在四肢（P = 0.006）。疼痛会影响日常生活的各个方面，但患者在生活享受和与他人的关系方面的控制能力要强于对照组。对64名患者（占疼痛者的70.3％）和24名对照（占疼痛者的45.3％）（P = 0.003）进行了疼痛治疗，最常见的是使用非甾体类抗炎药。 ALS病例也比对照组更常开非阿片类镇痛药和阿片类药物。结论：我们的研究表明，在ALS的所有阶段，疼痛都是常见的，但是它却常常未被充分认识和治疗。与基于人群的对照组相比，ALS患者的发病率明显更高。未来的研究需要阐明ALS中疼痛的机制，并确定最有效的治疗策略。

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