...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Serum cholesterol levels and survival after rtPA treatment in acute stroke
【24h】

Serum cholesterol levels and survival after rtPA treatment in acute stroke

机译：rtPA治疗后急性卒中的血清胆固醇水平和生存率

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: According to the reverse epidemiology hypothesis, high cholesterol levels might be protective and associated with greater survival rates under certain conditions. In stroke patients, a clear correlation between lipid levels and mortality after ischaemic and hemorrhagic strokes has been demonstrated. The aim of this study was to analyze the impact of lipid levels on 3-month mortality in patients with ischaemic stroke (IS) homogeneously treated with intravenous rtPA and admitted to a monitored acute stroke unit. Methods: Retrospective analysis of a prospective cohort of 220 patients with an IS treated with rtPA within the first 4.5h in a single tertiary hospital from January 2005 to August 2010. Results: Mortality at 3months was 15.0%. Univariate analysis showed that age, NIHSS at admission, heart failure, and atrial fibrillation were directly related to 3-month mortality; cholesterol, triglycerides, and low density lipoprotein were inversely associated. The death rate by cholesterol level was 5.5% for the highest tertile (>192mg/dl), 13.7% for the middle (192-155mg/dl), and 25.7% for the lowest (<155mg/dl), P=0.003. Multivariate analysis showed that amongst the lipid determinations, only cholesterol [OR: 0.985 (95% CI: 0.972-0.998), P=0.021] was inversely associated with 3-month mortality. The 'protective' effect of cholesterol was independent of stroke severity and remained significant in non-lacunar strokes. Conclusions: Survival of stroke patients receiving current, most effective medical treatment is related to blood cholesterol levels, with an inverse relationship between cholesterol and mortality. The mechanism of this apparently paradoxical situation remains unexplained but merits further research.
机译：背景：根据逆流行病学假说，高胆固醇水平在某些情况下可能具有保护性，并可能提高生存率。在中风患者中，已证明在缺血性和出血性中风后血脂水平与死亡率之间存在明显的相关性。这项研究的目的是分析血脂水平对接受rtPA静脉均匀治疗并接受监测的急性卒中患者的缺血性卒中（IS）患者3个月死亡率的影响。方法：回顾性分析2005年1月至2010年8月在一家三级医院进行的前4.5小时内接受rtPA治疗的220例IS患者的前瞻性队列研究。结果：3个月的死亡率为15.0％。单因素分析表明，年龄，入院时的NIHSS，心力衰竭和心房颤动与3个月的死亡率直接相关。胆固醇，甘油三酸酯和低密度脂蛋白呈负相关。最高三分位数（> 192mg / dl）的胆固醇死亡率为5.5％，中部（192-155mg / dl）的胆固醇死亡率为13.7％，最低三分位数（<155mg / dl）的胆固醇为25.7％，P = 0.003。多变量分析表明，在血脂测定中，只有胆固醇[OR：0.985（95％CI：0.972-0.998），P = 0.021]与3个月的死亡率呈负相关。胆固醇的“保护性”作用与卒中严重程度无关，在非腔隙性卒中中仍然很明显。结论：目前接受最有效药物治疗的中风患者的生存与血液中的胆固醇水平有关，胆固醇与死亡率之间呈反比关系。这种明显自相矛盾的情况的机制尚不清楚，但值得进一步研究。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号