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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Serum 25-hydroxyvitamin D predicts severity and prognosis in stroke patients
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Serum 25-hydroxyvitamin D predicts severity and prognosis in stroke patients

机译：血清25-羟基维生素D预测中风患者的严重程度和预后

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Background and purpose: We aimed to evaluate the association between 25-hydroxyvitamin D (25(OH)D) levels and both clinical severity at admission and outcome at discharge in stroke patients. Methods: From February 2010 to December 2010, consecutive stroke patients admitted to the Department of Neurology of Dijon, France, were identified. Clinical information was collected. Serum concentration of 25(OH)D was measured at baseline. Stroke severity was assessed at admission using the NIHSS score. Functional impairment was evaluated at discharge using the modified Rankin scale (m-Rankin). Multivariate analyses were performed using logistic regression models. Results: Of the 386 recorded patients, serum 25(OH)D levels were obtained in 382 (median value = 35.1-nM; IQR = 21-57.8). At admission, 208 patients had a NIHSS ≤5, with a higher mean 25(OH)D level than that observed in patients with moderate-to-high severity (45.9 vs. 38.6-nM, P-<-0.001). In multivariate analyses, a 25(OH)D level in the lowest tertile (<25.7-nM) was a predictor of a NIHSS ≥6 (OR = 1.67; 95% CI = 1.05-2.68; P = 0.03). The mean 25(OH)D level was lower in patients with moderate-to-severe handicap at discharge (m-Rankin 3-6) than in patients with no or mild handicap (35.0 vs. 47.5-nM, P-<-0.001). In multivariate analyses, the lowest tertile of 25(OH)D level (<25.7-nM) was associated with a higher risk of moderate-to-severe handicap (OR = 2.06; 95% CI = 1.06-3.94; P = 0.03). Conclusion: A low serum 25(OH)D level is a predictor of both severity at admission and poor early functional outcome in stroke patients. The underlying mechanisms of these associations remain to be investigated.
机译：背景与目的：我们旨在评估卒中患者25-羟基维生素D（25（OH）D）水平与入院时临床严重程度和出院结局之间的关系。方法：从2010年2月至2010年12月，确定法国第戎神经内科连续住院的卒中患者。收集临床信息。在基线时测量血清25（OH）D浓度。入院时使用NIHSS评分评估卒中严重程度。使用改良的兰金量表（m-Rankin）评估出院时的功能障碍。使用逻辑回归模型进行多变量分析。结果：在386名记录的患者中，有382名获得了血清25（OH）D水平（中值= 35.1-nM; IQR = 21-57.8）。入院时，208名患者的NIHSS≤5，其平均25（OH）D水平高于中至高严重性患者的观察值（45.9 vs. 38.6-nM，P-<-0.001）。在多变量分析中，最低三分位数（<25.7-nM）中的25（OH）D水平是NIHSS≥6的预测指标（OR = 1.67; 95％CI = 1.05-2.68; P = 0.03）。出院时中度至重度残疾的患者（m-Rankin 3-6）的平均25（OH）D水平低于无或轻度残疾的患者（35.0 vs.47.5-nM，P-<-0.001 ）。在多变量分析中，最低25（OH）D水平（<25.7-nM）与较高的中度至重度残障风险相关（OR = 2.06; 95％CI = 1.06-3.94; P = 0.03） 。结论：较低的血清25（OH）D水平可预测卒中患者入院时的严重程度和较差的早期功能结局。这些协会的潜在机制仍有待研究。

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