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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Chronic subthalamic high-frequency deep brain stimulation in Parkinson's disease--a histopathological study.
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Chronic subthalamic high-frequency deep brain stimulation in Parkinson's disease--a histopathological study.

机译：帕金森氏病的慢性丘脑高频深部脑刺激-组织病理学研究。

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摘要

This study describes the pathological findings in the brain of a patient with Parkinson's disease (PD) treated with bilateral subthalamic high-frequency deep brain stimulation (STN DBS) for 29 months prior to death. After routine neuropathological examination, tissue blocks containing the electrode tracts, the subthalamic nucleus (STN), the substantia nigra and the pre-frontal cortex were paraffin embedded and cut into 5-microm-thick serial sections and stained with several conventional staining methods and immunohistochemistry. Bilateral nigral depigmentation, cell loss and Lewy body formation confirmed the diagnosis of PD. Microscopic evaluation furthermore confirmed the location of the electrodes in the STN. The electrode tracts were surrounded by a 150-microm-wide glial fibrillary acidic protein (GFAP)-positive capsule consisting of a thin collagen layer lining the lumen of the tract, whilst an area with few cells and axons constituted the capsule wall towards the surrounding normal brain tissue. The brain tissue appeared normal outside the capsule boundaries with no difference in areas of stimulation compared with areas of no stimulation. Our results correspond with previous studies performed after fewer months of STN DBS and indicate mild histopathological changes in the vicinity of the electrode tract, appearing to result from the electrode placement and not from the electrical stimulation.
机译：这项研究描述了死亡前29个月接受双侧丘脑高频深部脑刺激（STN DBS）治疗的帕金森氏病（PD）患者大脑的病理发现。经过常规的神经病理学检查，将包含电极束，丘脑下核（STN），黑质和前额叶皮层的组织块石蜡包埋，切成5微米厚的连续切片，并用几种常规染色方法和免疫组织化学染色。双边黑色素脱色，细胞丢失和路易体形成证实了PD的诊断。显微镜评估进一步证实了电极在STN中的位置。电极束被一个150微米宽的神经胶质纤维酸性蛋白（GFAP）阳性囊膜包围，该囊膜由一层薄薄的胶原蛋白层覆盖在管腔内，而几乎没有细胞和轴突的区域构成了向周围的囊壁正常的脑组织。与无刺激的区域相比，脑组织在囊膜边界外显得正常，没有刺激区域。我们的结果与先前的STN DBS数月后进行的研究相对应，表明在电极束附近出现轻微的组织病理学变化，这似乎是由于电极放置而不是电刺激引起的。

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