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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Epilepsy associated with glutamic acid decarboxylase antibody (GADA)
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Epilepsy associated with glutamic acid decarboxylase antibody (GADA)

机译：谷氨酸脱羧酶抗体（GADA）相关的癫痫

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摘要

There is increasing evidence from several case series and case reports of the clinical importance of glutamic acid decarboxylase antibody (GADA)-associated epilepsy. It seems that especially temporal lobe epilepsy (TLE) is associated with GADA-associated epilepsy [1,2] as well as with other epilepsies with immunological dysfunction [3,4]. The mechanisms of immune system activation in TLE is partly explained by the particular neurobiolog-ical vulnerability of temporal lobe, abundance of projections of temporal lobe to other brain regions, and the close relationship of mesiotemporal structures and hypophysis-pituitary-adrenal (HPA) axis.This study of Falip and co-workers in this journal introduces the detailed clinical-immunological characteristics of GAD A in patients with TLE [5]. They studied 42 consecutive adult TLE patients: 12% of these patients harbored GADA and 4.8% of the patients had high ti-ters of GADA. In addition, they presented a separate group of seven patients with high titer GADA and TLE. Several autoimmune diseases were found in these GADA positive patients. Previous reports have already suggested the association of autoimmune diseases and other autoantibodies with high titers of GADA.
机译：越来越多的证据表明，谷氨酸脱羧酶抗体（GADA）相关性癫痫的临床重要性来自多个病例系列和病例报告。似乎特别是颞叶癫痫（TLE）与GADA相关癫痫[1,2]以及其他具有免疫功能障碍的癫痫[3,4]有关。 TLE中免疫系统激活的机制部分由颞叶的特定神经生物学脆弱性，颞叶向其他大脑区域的丰富投射以及中颞叶结构与垂体-垂体-肾上腺（HPA）轴的紧密关系来部分解释这项关于Falip及其同事的研究介绍了GAD A在TLE患者中的详细临床免疫学特征[5]。他们研究了连续42例成人TLE患者：其中12％的患者患有GADA，4.8％的患者具有较高的GADA滴度。此外，他们还提出了另外一组7例高滴度GADA和TLE的患者。在这些GADA阳性患者中发现了几种自身免疫性疾病。先前的报道已经提示自身免疫性疾病和其他自身抗体与高滴度的GADA相关。

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