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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Admission hyperglycemia causes infarct volume expansion in patients with ICA or MCA occlusion: Association of collateral grade on conventional angiography
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Admission hyperglycemia causes infarct volume expansion in patients with ICA or MCA occlusion: Association of collateral grade on conventional angiography

机译：入院高血糖症导致ICA或MCA闭塞患者的梗死体积扩大：传统血管造影上的侧支级联

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Background and purpose: Hyperglycemia (HG) is associated with infarct volume expansion in acute ischaemic stroke patients. However, collateral circulation can sustain the ischaemic penumbra and limit the growth of infarct volume. The aim of this study was to determine whether the association between HG and infarct volume expansion is dependent on collateral circulation. Methods: We performed a retrospective analysis of 93 acute ischaemic stroke patients with internal carotid artery or middle cerebral artery occlusion within 24 h of onset were retrospectively studied. HG was diagnosed in patients with an admitting blood glucose value ≥140 mg/dl. Angiographic collateral grade 0-1 was designated as poor collateral circulation and grade 2-4 as good collateral circulation. Infarct volume was measured at admission and at again within 7 days using diffusion-weighted magnetic resonance images. Results: Among 34 patients with poor collateral grade, the change in infarct volume was significantly greater in the HG group than in the non-HG group (106.0 ml vs. 22.7 ml, P = 0.002). Among the 59 patients with good collateral circulation, the change in infarct volume was greater in the HG group than in the non-HG group (53.3 ml vs. 10.9 ml, P = 0.047). Multiple regression analysis indicated that admission HG (P = 0.004), baseline National Institutes of Health Stroke Scale score (P = 0.018), and poor collateral circulation (P = 0.040) were independently associated with infarct volume expansion. Conclusions: Infarct volume expansion was greater in individuals with HG on admission regardless of collateral circulation status.
机译：背景与目的：高血糖（HG）与急性缺血性中风患者的梗死体积扩大有关。但是，侧支循环可以维持缺血性半影​​并限制梗死体积的增长。这项研究的目的是确定HG和梗死体积扩大之间的关联是否取决于侧支循环。方法：我们对93例急性缺血性脑卒中患者在发病后24小时内颈内动脉或大脑中动脉阻塞的情况进行了回顾性分析。入院血糖值≥140mg / dl的患者被诊断为HG。血管造影侧支0-1级被指定为不良侧支循环，2-4级被定为良好的侧支循环。使用扩散加权磁共振图像在入院时和在7天内再次测量梗塞体积。结果：在34例侧支分级不良的患者中，HG组的梗死体积变化明显大于非HG组（106.0 ml对22.7 ml，P = 0.002）。在59例侧支循环良好的患者中，HG组的梗死体积变化大于非HG组（53.3 ml对10.9 ml，P = 0.047）。多元回归分析表明，入院HG（P = 0.004），美国国立卫生研究院卒中量表基线评分（P = 0.018）和侧支循环不良（P = 0.040）与梗死面积扩大独立相关。结论：无论侧支循环状态如何，入院后HG患者的梗死体积扩大都更大。

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