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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >White matter reduced streamline coherence in young men with autism and mental retardation.
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White matter reduced streamline coherence in young men with autism and mental retardation.

机译：白质降低了患有自闭症和智力低下的年轻人的流线型连贯性。

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BACKGROUND AND PURPOSE: It has been proposed that white matter alterations might play a role in autistic disorders; however, published data are mainly limited to high-functioning autism. The goal of this study was to apply diffusion tensor imaging (DTI) and fiber tractography (FT) to study white matter in low-functioning autism and the relationship between white matter and cognitive impairment. METHODS: Ten low-functioning males with autism (mean age: 19.7 +/- 2.83 years) and 10 age-matched healthy males (mean age: 19.9 +/- 2.64 years) underwent DTI-MRI scanning. fractional anisotropy (FA) maps were analyzed with whole brain voxel-wise and tract-of-interest statistics. Using FT algorithms, white matter tracts connecting the orbitofrontal cortex (OFC) with other brain regions were identified and compared between the two groups. FA mean values of the autistic group were correlated with intelligence quotient (IQ) scores. RESULTS: Low-functioning autistic subjects showed a reduced tract volume and lower mean FA values in the left OFC network compared with controls. In the autistic group, lower FA values were associated with lower IQ scores. CONCLUSIONS: We showed evidence of OFC white matter network abnormalities in low-functioning autistic individuals. Our results point to a relationship between the severity of the intellectual impairment and the extent of white matter alterations.
机译：背景与目的：已提出白质改变可能在自闭症中起作用。但是，已发表的数据主要限于高功能自闭症。这项研究的目的是应用弥散张量成像（DTI）和纤维束成像（FT）来研究低功能自闭症中的白质以及白质与认知障碍之间的关系。方法：对10例自闭症低功能男性（平均年龄：19.7 +/- 2.83岁）和10例年龄相匹配的健康男性（平均年龄：19.9 +/- 2.64岁）进行了DTI-MRI扫描。分数各向异性（FA）图用全脑体素和感兴趣区域统计数据进行了分析。使用FT算法，识别并连接了眶额叶皮层（OFC）与其他大脑区域的白质束，并进行了比较。自闭症组的FA平均值与智商（IQ）得分相关。结果：与对照组相比，低功能自闭症受试者的左侧OFC网络显示的管道体积减少，平均FA值降低。在自闭症组中，较低的FA值与较低的IQ分数相关。结论：我们显示了低功能自闭症患者中OFC白质网络异常的证据。我们的结果表明，智力障碍的严重程度与白质改变的程度之间存在关联。

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