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首页> 外文期刊>European journal of clinical nutrition >Efficacy of a multi-micronutrient dietary intervention based on haemoglobin, hair zinc concentrations, and selected functional outcomes in rural Malawian children.
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Efficacy of a multi-micronutrient dietary intervention based on haemoglobin, hair zinc concentrations, and selected functional outcomes in rural Malawian children.

机译：在马拉维农村儿童中，基于血红蛋白，头发锌浓度和特定功能结局的多种微量营养素饮食干预的功效。

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OBJECTIVE: To investigate the efficacy of enhancing the content and bioavailability of micronutrients in diets of stunted rural Malawian children on their growth and body composition, morbidity, anaemia and hair zinc concentrations. DESIGN: A quasi-experimental design with non-equivalent control group involving 410 intervention and 220 control children aged 30-90 months. SETTING AND SUBJECTS: Children from two intervention and two control villages in Mangochi District, Southern Malawi participated in a 6 month dietary intervention. Anthropometry, malarial screening, haemoglobin, and hair zinc were measured at baseline and after 12 months, as well as socio-economic status at baseline, and common infections monthly post-intervention. RESULTS: Groups were comparable at baseline. Post-intervention children had greater Z-scores for lean body mass (mid-upper arm circumference -0.75 vs -1.05; arm muscle area: 0.63 vs -1.03, P<0.001) than controls but Z-scores for weight-for-height and height-for-age were similar. After controlling for baseline variables, mean haemoglobin was higher (107 vs 102 g/l, P<0.01), whereas the incidence of both anaemia (62 vs 80%) and common infections (based on a median overall illness score for fever, diarrhoea, upper and lower respiratory infections) were lower in intervention compared to controls, with no change in hair zinc concentrations or malaria status post-intervention. CONCLUSION: Improvements in the micronutrient adequacy of diets of post-intervention children were associated with a favourable increase in indices of lean body mass and reductions in the incidence of anaemia and common infections in these rural Malawian stunted children. SPONSORSHIP: Canadian International Development Agency through Micronutrient Initiative, UNICEF Malawi, World Vision Malawi. SmithKline Beecham donated albendazole. doi:10.1038/sj.ejcn.1601469
机译：目的：研究提高发育不良的马拉维农村儿童饮食中微量营养素含量和生物利用度对他们的生长和身体组成，发病率，贫血和头发锌浓度的功效。设计：采用非等效对照组的准实验设计，涉及410名干预者和220名年龄在30-90个月的对照儿童。地点和受试者：来自马拉维南部Mangochi区的两个干预村和两个控制村的孩子参加了为期6个月的饮食干预。在基线和12个月后测量人体测量学，疟疾筛查，血红蛋白和头发锌含量，以及基线时的社会经济状况和干预后每月的常见感染。结果：各组在基线时具有可比性。干预后儿童的瘦体重Z评分（上臂中段-0.75 vs -1.05;手臂肌肉面积：0.63 vs -1.03，P <0.001）比对照组高，但身高体重的Z评分和年龄高度相似。在控制了基线变量之后，平均血红蛋白较高（107 vs 102 g / l，P <0.01），而贫血（62 vs 80％）和常见感染的发生率（基于发烧，腹泻的总体疾病中位数） ，上呼吸道感染和下呼吸道感染）比对照组低，干预后头发锌浓度或疟疾状况无变化。结论：干预后儿童饮食中微量营养素的充足与瘦体重指数的有利增加以及这些马拉维发育不良的农村儿童贫血和常见感染的发生率降低相关。赞助：加拿大国际开发署通过微量营养素计划，联合国儿童基金会马拉维，马拉维世界宣明会。 SmithKline Beecham捐赠了阿苯达唑。 doi：10.1038 / sj.ejcn.1601469

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