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首页> 外文期刊>European journal of clinical nutrition >Timing of complementary food introduction and age at diagnosis of type 1 diabetes: The SEARCH nutrition ancillary study (SNAS)
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Timing of complementary food introduction and age at diagnosis of type 1 diabetes: The SEARCH nutrition ancillary study (SNAS)

机译：补充食物的引入时间和诊断1型糖尿病的年龄：SEARCH营养辅助研究（SNAS）

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The association between timing of complementary food introduction and age at diagnosis of type 1 diabetes was investigated among 1077 children in the SEARCH for Diabetes in Youth study. Age at diagnosis was 5 months earlier for children introduced to sugar-sweetened beverages (SSB) in the first 12 months of life compared with those who were not (9.0±0.2 vs 9.5±0.1; P=0.02) independent of human leukocyte antigen (HLA) risk status. Analyses stratified by HLA risk status found that children with a high-risk HLA genotype had an earlier age at diagnosis if they were introduced to fruit juice in the first year of life (mean age at diagnosis=9.3±0.1, 9.1±0.1 and 9.6±0.2 for introduction at ≤6 months, between 7 and 11 months and ≥12 months, respectively; P=0.04). Introduction of SSB in the first year of life may accelerate the onset of type 1 diabetes independent of HLA risk status.
机译：在“青少年糖尿病研究”中的1077名儿童中，调查了补充食物的导入时间与诊断1型糖尿病的年龄之间的关系。与不依赖人类白细胞抗原的儿童（9.0±0.2比9.5±0.1; P = 0.02）的儿童相比，出生后前12个月接受糖分饮料（SSB）的儿童的诊断年龄要早5个月（ HLA）风险状态。根据HLA风险状态进行的分层分析发现，如果将高风险HLA基因型的儿童在生命的第一年引入果汁，则他们的诊断年龄会早些（诊断时的平均年龄为9.3±0.1、9.1±0.1和9.6） ≤6个月，7到11个月和≥12个月的引入分别为±0.2; P = 0.04）。在出生的第一年引入SSB可能会加速1型糖尿病的发作，而与HLA风险状况无关。

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