• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>European journal of clinical nutrition >Retinol, alpha-tocopherol and carotenoids in diabetes.
【24h】

Retinol, alpha-tocopherol and carotenoids in diabetes.

机译：糖尿病中的视黄醇，α-生育酚和类胡萝卜素。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: A case-control study was conducted to evaluate the effects of diabetes mellitus on serum levels of vitamin A, alpha-carotene, beta-carotene, alpha-tocopherol, serum and urine RBP. SUBJECTS: One hundred and seven patients with Type 2 diabetes mellitus (28-74 y) were recruited from those attending a primary health care clinic in King Khalid University Hospital in Riyadh City (Saudi Arabia). They were matched for age and sex with 143 healthy individuals. METHODS: Fasting blood samples and 10h urine collections were obtained from all subjects. Levels of vitamins and carotenoids in serum measured by high performance liquid chromatography (HPLC), and of retinol binding protein (RBP) in serum and urine by an enzyme-linked immunosorbent assay (ELISA). RESULTS: The mean serum concentrations of retinol, alpha-carotene, and alpha-tocopherol were similar in both groups after correction of lipid soluble vitamins for serum lipids levels. However, serum beta-carotene concentration was significantly higher in control subjects than diabetics (P = 0.002). Serum and urine RBP concentrations were significantly higher in diabetics than in controls (P = 0.0001). In normal subjects (but not diabetics) serum concentrations of retinol and RBP were higher in men than in women (P = 0.02, P = 0.0001 respectively). In both normal and diabetic subjects, serum levels of alpha-tocopherol (P = 0.007) and urine RBP (P = 0.005), were higher in men than women. Urinary excretion of RBP was significantly higher in diabetic patients with renal impairment than other diabetics or controls (P = 0.0001). There was a negative correlation between fasting blood glucose (FBG) concentration and serum beta-carotene (P = 0.008) in the total combined group and a positive correlation between FBG and urinary RBP/creatinine (P = 0.009) in diabetic patients. CONCLUSION: Serum beta-carotene concentration was significantly lower in diabetic patients than controls. Serum retinol concentration in patients with diabetes was normal, yet serum and urine RBP concentrations were significantly higher in diabetics than in controls.
机译：目的：进行了一项病例对照研究，以评估糖尿病对血清维生素A，α-胡萝卜素，β-胡萝卜素，α-生育酚，血清和尿RBP水平的影响。研究对象从沙特阿拉伯利雅得市国王哈立德大学医院就诊的初级卫生保健诊所招募了107例2型糖尿病（28-74岁）患者。他们按年龄和性别匹配了143名健康个体。方法：从所有受试者获得空腹血液样本和10小时尿液收集。通过高效液相色谱（HPLC）测定的血清中维生素和类胡萝卜素的水平，以及通过酶联免疫吸附测定（ELISA）测定的血清和尿液中视黄醇结合蛋白（RBP）的水平。结果：校正了脂溶性维生素的血脂水平后，两组的平均视黄醇，α-胡萝卜素和α-生育酚浓度相似。然而，对照组的血清β-胡萝卜素浓度显着高于糖尿病患者（P = 0.002）。糖尿病患者的血清和尿液RBP浓度显着高于对照组（P = 0.0001）。在正常受试者（而非糖尿病患者）中，男性的视黄醇和RBP的血清浓度高于女性（分别为P = 0.02，P = 0.0001）。在正常人和糖尿病人中，男性的血清α-生育酚水平（P = 0.007）和尿RBP（P = 0.005）高于女性。肾功能不全的糖尿病患者尿中RBP的排泄量明显高于其他糖尿病患者或对照组（P = 0.0001）。合并组中空腹血糖（FBG）浓度与血清β-胡萝卜素（P = 0.008）呈负相关，糖尿病患者FBG与尿RBP /肌酐（P = 0.009）呈正相关。结论：糖尿病患者的血清β-胡萝卜素浓度显着低于对照组。糖尿病患者的血清视黄醇浓度正常，但糖尿病患者的血清和尿液RBP浓度明显高于对照组。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号