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首页> 外文期刊>European journal of clinical nutrition >Plasma AA and DHA levels are not compromised in newly diagnosed gestational diabetic women.
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Plasma AA and DHA levels are not compromised in newly diagnosed gestational diabetic women.

机译：在新诊断的妊娠糖尿病妇女中，血浆AA和DHA水平不会受到影响。

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OBJECTIVE: The polyunsaturated fatty acids, arachidonic (AA) and docosahexaenoic (DHA), are vital structural and functional components of the neural, vascular and visual systems. There is increased demand for these fatty acids during pregnancy. Diabetes impairs the synthesis of both AA and DHA. We have investigated the possibility that pregnancy-induced diabetes compromises the levels of plasma AA and DHA in newly diagnosed expectant mothers. DESIGN: Cross-sectional study. SETTING: London, UK. SUBJECTS AND METHODS: Venous blood was obtained from 44 women with gestational diabetes mellitus (GDM) and from the same number of nondiabetics, during the third trimester. Fatty acid composition of plasma choline phosphoglycerides (CPG), triglycerides (TG) and cholesterol esters (CE) was analysed. RESULTS: The GDM women had higher levels of AA (20:4n-6; P<0.0001) and AA/linoleic acid ratio (20:4n-6/18:2n-6; P<0.01) in the CPG, and linoleic acid (LA; P<0.0001), total n-6 (P<0.01), DHA (P<0.05) and n-3 metabolites(P<0.05) in TG compared to their nondiabetic counterparts. Similarly, AA (P<0.0001), osbond acid (22:5n-6; P<0.05), total n-6 metabolites (P<0.0001), AA/LA (P<0.0001) and n-6 metabolites/LA (P<0.01) were higher in the CE of the GDM women. There was no difference in the levels of DHA in CPG and CE between the two groups (P>0.05). CONCLUSIONS: The results of this study do not provide evidence that the activity of delta-6 or delta-5 desaturases, which are vital for the synthesis of AA and DHA, is compromised by pregnancy-induced diabetes. However, since the samples were taken at diagnosis, it is conceivable that the duration of the diabetes was too short to have a discernable adverse effect on the levels of AA and DHA in plasma lipids.
机译：目的：多不饱和脂肪酸，花生四烯酸（AA）和二十二碳六烯酸（DHA），是神经，血管和视觉系统的重要结构和功能组件。在怀孕期间对这些脂肪酸的需求增加。糖尿病损害AA和DHA的合成。我们调查了妊娠诱发的糖尿病损害了新诊断的准妈妈血浆AA和DHA水平的可能性。设计：横断面研究。地点：英国伦敦。研究对象和方法：在妊娠中期，从44名妊娠糖尿病（GDM）妇女和相同数量的非糖尿病患者中抽取静脉血。分析血浆胆碱磷酸甘油酯（CPG），甘油三酸酯（TG）和胆固醇酯（CE）的脂肪酸组成。结果：GDM妇女的CPG和亚油酸水平较高，AA（20：4n-6; P <0.0001）和AA /亚油酸比率（20：4n-6 / 18：2n-6; P <0.01）较高。与非糖尿病患者相比，TG中的酸（LA; P <0.0001），总n-6（P <0.01），DHA（P <0.05）和n-3代谢物（P <0.05）。同样地，AA（P <0.0001），奥斯本酸（22：5n-6; P <0.05），总n-6代谢物（P <0.0001），AA / LA（P <0.0001）和n-6代谢物/ LA（ P <0.01）在GDM女性的CE中较高。两组的CPG和CE中DHA水平无差异（P> 0.05）。结论：这项研究的结果没有提供证据表明，对于孕妇和孕妇而言，对合成AA和DHA至关重要的delta-6或delta-5脱氢酶的活性受到损害。但是，由于样品是在诊断时采集的，因此可以想象，糖尿病的持续时间太短，以至于无法对血浆脂质中的AA和DHA水平产生明显的不良影响。

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