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首页> 外文期刊>European journal of clinical nutrition >Effect of oral iodized oil on thyroid size and thyroid hormone metabolism in children with concurrent selenium and iodine deficiency.
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Effect of oral iodized oil on thyroid size and thyroid hormone metabolism in children with concurrent selenium and iodine deficiency.

机译：口服碘油对伴有硒和碘缺乏症的儿童的甲状腺大小和甲状腺激素代谢的影响。

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OBJECTIVES: To determine the efficacy of oral iodized oil in goitrous children who are both selenium (Se) and iodine deficient; to investigate if Se status modifies the response of iodine deficient, goitrous children to oral supplementation with iodized oil. DESIGN: A longitudinal intervention trial. SETTING: Two rural villages in the western Cote d'Ivoire. SUBJECTS: 51 goitrous non-anemic schoolchildren with both iodine and Se deficiency. INTERVENTION: Each child received an oral dose of 0.4 ml iodized poppyseed oil containing 200 mg of iodine. They were followed for 1 y with measurements of urinary iodine (UI), thyrotropin (TSH), thyroxine (T4), and thyroid volume by ultrasound. RESULTS: At baseline all children were goitrous and Se deficient; median UI was 29 microg/l and mean serum Se (s.d.) was 14.8 (10.7) microg/l. After receiving iodized oil, thyroid volume decreased significantly vs baseline at 10, 15, 30 and 50 weeks (P<0.001). At 50 weeks mean percentage change in thyroid volume from baseline was-46.6% and only five children remained goitrous. Median TSH values at 5, 10, 15, 30 and 50 weeks were reduced significantly (P<0.001) compared to baseline. Among individual children the severity of Se deficiency predicted the degree of response to iodized oil. Baseline serum Se and percentage change in thyroid volume from baseline at 50 weeks were strongly correlated (r2=0.554). Baseline Se and percentage decrease in TSH from baseline at 30 weeks were also well-correlated (r2=0.467). CONCLUSION: Although more severe Se deficiency partially blunts the thyroid response to iodine supplementation, oral iodized oil is an effective method for iodine repletion in goitrous children who are Se deficient. SPONSORSHIP: The Swiss Federal Institute of Technology, Zurich, the Foundation for Micronutrients in Medicine, Rapperswil, Switzerland, and the Thrasher Research Fund, Salt Lake City, USA.
机译：目的：确定口服碘油对缺硒和缺碘的甲状腺肿儿童的疗效;调查硒状态是否会改善碘缺乏症，甲状腺肿大的儿童口服碘化油补充的反应。设计：一项纵向干预试验。地点：科特迪瓦西部的两个乡村。受试者：51名患有碘和硒缺乏症的甲状腺肿非贫血学童。干预措施：每个孩子口服0.4 ml含200 mg碘的加碘罂粟籽油。随访1年，通过超声测量尿碘（UI），促甲状腺激素（TSH），甲状腺素（T4）和甲状腺体积。结果：在基线时，所有儿童均为甲状腺肿且缺乏硒。 UI中位数为29微克/升，平均血清硒（标准误）为14.8（10.7）微克/升。接受加碘油后，在第10、15、30和50周时，甲状腺体积较基线显着减少（P <0.001）。在第50周时，甲状腺体积相对于基线的平均百分比变化为-46.6％，只有5名儿童患有甲状腺肿。与基线相比，第5、10、15、30和50周的中值TSH值显着降低（P <0.001）。在个别儿童中，硒缺乏的严重程度预示了对碘油的反应程度。基线血清硒与甲状腺在50周时相对于基线的百分比变化具有高度相关性（r2 = 0.554）。 30周时，基线硒和TSH相对于基线的降低百分比也具有良好的相关性（r2 = 0.467）。结论：尽管更严重的硒缺乏会部分减弱甲状腺对碘补充的反应，但口服碘油是一种有效的补充硒缺乏的甲状腺肿儿童的碘的方法。发起人：瑞士苏黎世联邦理工学院，瑞士拉珀斯维尔的医学微量营养素基金会和美国盐湖城的Thrasher研究基金。

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