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首页> 外文期刊>European journal of clinical nutrition >Arachidonic and docosahexaenoic acids are strongly associated in maternal and neonatal blood.
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Arachidonic and docosahexaenoic acids are strongly associated in maternal and neonatal blood.

机译：花生四烯酸和二十二碳六烯酸在孕妇和新生儿血液中密切相关。

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BACKGROUND: The red cell membrane fatty acid composition has frequently been used as an index of essential fatty acid (EFA) nutrition. After birth there is a decline in plasma arachidonic acid (AA) and docosahexaenoic (DHA) acids in babies fed on conventional formula which contains only the parent linoleic and alpha-linolenic acids. In human studies, the red cell phosphoglyceride composition appears to be more constant than that of plasma. In infants fed fish oil without AA, the AA proportions fall in the plasma but much less so in the red cells. This result might be considered to mean that there is no need for preformed AA. On the other hand, in a study where the levels of AA fell there was reduction of infant growth. Indeed, where cell membrane composition does change there is often an associated alteration in physiological functions of membranes. We therefore felt it worth investigating the balance between AA and DHA in a physiological situation where plasma levels are known to change, namely in pregnancy. PURPOSE: The aim of the study was to investigate a relationship between blood phosphoglyceride AA and DHA in pregnant women and neonates. SUBJECTS: Health pregnant women from London, England (n=193) and their term babies (n=45); healthy pregnant women from Seoul, South Korea (n=40) and their term babies (n=40); and preterm neonates (n=72) from London. METHOD: Blood samples were taken from British and Korean pregnant women during the third trimester, and from term and preterm babies at birth. These samples were taken for routine monitoring purposes in Korea and were a part of a study on pregnancy outcome for which ethical permission was granted from the East London and The City Health Authority and Lambeth, Southwark and Lewisham Health Authority. Approval was also obtained from the Ethical Committee of the Asan Medical Centre, Seoul, South Korea. RESULTS: AA and DHA correlated in plasma choline phosphoglycerides (CPG) of the British mothers (r=0.52 P<0.0001). The correlation coefficients and significance were much stronger in the red cell CPG and even more so in the term and preterm infant red cell CPGs ( r=0.75, 0.80 and 0.88, respectively). Similarly, AA and DHA correlated in red cell CPGs of the Korean women and their term babies. There was also a significant relationship between the two fatty acids in red cell ethanolamine phosphoglycerides in the mothers and their babies. Both linoleic (LA) and alpha-linolenic acids (ALA) were inversely associated with AA and DHA in some of the phosphoglyceride fractions of the mothers and babies. CONCLUSIONS: Although AA and DHA have different primary dietary origins, there were significant relationships between AA and DHA in the phosphoglycerides of the red cell membrane. This finding seems surprising if the red cell composition is determined by diet. These results suggest a physiological mechanism which attempts to maintain an appropriate balance between AA and DHA. It is plausible that there is an optimum balance between AA and DHA for membrane stability, deformability, enzyme and receptor function. SPONSORSHIP: The British Diabetic Association, March of Dimes Birth Defects Foundation and The Christopher H.R. Reeves Charitable Trust. European Journal of Clinical Nutrition (2000) 54, 50-56
机译：背景：红细胞膜脂肪酸成分经常被用作必需脂肪酸（EFA）营养的指标。出生后，按常规配方喂养的婴儿中血浆花生四烯酸（AA）和二十二碳六烯酸（DHA）的含量有所下降，这种配方仅包含母体亚油酸和α-亚麻酸。在人体研究中，红细胞磷酸甘油酯的组成似乎比血浆更稳定。在没有AA的鱼油喂养的婴儿中，血浆中AA的含量下降，但在红细胞中的下降幅度要小得多。可以认为该结果意味着不需要预制的AA。另一方面，在一项AA水平下降的研究中，婴儿的生长减少了。实际上，在细胞膜组成确实发生变化的地方，膜的生理功能通常会发生相关变化。因此，我们认为有必要在已知血浆水平发生变化的生理情况下（即在怀孕期间）研究AA和DHA之间的平衡。目的：该研究的目的是研究孕妇和新生儿血液中磷酸甘油酯AA和DHA之间的关系。研究对象：英国伦敦的健康孕妇（n = 193）及其足月婴儿（n = 45）;来自韩国首尔的健康孕妇（n = 40）及其足月婴儿（n = 40）;和伦敦的早产儿（n = 72）。方法：在妊娠中期从英国和韩国孕妇以及足月和早产儿中抽取血液。这些样本是在韩国进行常规监测的目的，是妊娠结局研究的一部分，东伦敦和市卫生局以及兰贝斯，南华克和刘易舍姆卫生局均已就此事进行了伦理许可。还获得了韩国首尔牙山医学中心伦理委员会的批准。结果：英国母亲血浆胆碱磷酸甘油酯（CPG）中AA和DHA相关（r = 0.52 P <0.0001）。红细胞CPG中的相关系数和显着性要强得多，足月和早产儿红细胞CPG中的相关系数和显着性更强（分别为r = 0.75、0.80和0.88）。同样，AA和DHA与韩国妇女及其足月儿的红细胞CPG相关。母亲和婴儿的红细胞乙醇胺磷酸甘油酯中的两种脂肪酸之间也存在显着关系。在母亲和婴儿的某些磷酸甘油酯级分中，亚油酸（LA）和α-亚麻酸（ALA）与AA和DHA呈负相关。结论：尽管AA和DHA具有不同的主要饮食来源，但在红细胞膜的磷酸甘油酯中AA和DHA之间存在显着的关系。如果通过饮食确定红细胞组成，这一发现似乎令人惊讶。这些结果表明了试图维持AA和DHA之间适当平衡的生理机制。可以认为，AA和DHA在膜稳定性，可变形性，酶和受体功能方面具有最佳平衡。赞助：英国糖尿病协会，迪姆斯出生缺陷基金会三月和克里斯托弗·H·R·里夫斯慈善信托基金。欧洲临床营养学杂志（2000）54，50-56

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