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首页> 外文期刊>European journal of clinical nutrition >Effects of moderate alcohol consumption on folate and vitamin B(12) status in postmenopausal women.
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Effects of moderate alcohol consumption on folate and vitamin B(12) status in postmenopausal women.

机译：适度饮酒对绝经后妇女叶酸和维生素B（12）状态的影响。

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BACKGROUND: Although alcohol intake has been positively associated with breast cancer risk in epidemiologic studies, a causal relationship has not been established, and the mechanisms mediating this association are speculative. Alcohol may act through altered status of folate and vitamin B(12), two vitamins required for DNA methylation and nucleotide synthesis, and thus cell integrity. Although the effects of heavy alcohol intake on folate and vitamin B(12) status have been well-documented, few studies have addressed the effects of moderate alcohol intake in a controlled setting. OBJECTIVE: The objective of this study was to determine the effects of moderate alcohol intake on folate and vitamin B(12) status in healthy, well-nourished, postmenopausal women. DESIGN: The study design was a randomized, diet-controlled crossover intervention. Postmenopausal women (n=53) received three 8-week alcohol treatments in random order: 0, 15, and 30 g/day. Treatment periods were preceded by 2-5-week washout periods.Blood collected at baseline and week 8 of each treatment period was analyzed for serum folate, vitamin B(12), homocysteine (HCY), and methylmalonic acid (MMA) concentrations. RESULTS: After adjusting for body mass index (BMI), a significant 5% decrease was observed in mean serum vitamin B(12) concentrations from 0 to 30 g of alcohol/day (461.45+/-30.26 vs 440.25+/-30.24 pg/ml; P=0.03). Mean serum HCY concentrations tended to increase by 3% from 0 to 30 g of alcohol/day (9.44+/-0.37 vs 9.73+/-0.37 micromol/l; P=0.05). Alcohol intake had no significant effects on serum folate or MMA concentrations. CONCLUSIONS: Among healthy, well-nourished, postmenopausal women, moderate alcohol intake may diminish vitamin B(12) status.
机译：背景：尽管在流行病学研究中饮酒与乳腺癌风险呈正相关，但尚未建立因果关系，并且介导这种关联的机制尚属推测。酒精可能会通过改变叶酸和维生素B（12）的状态而起作用，叶酸和维生素B是DNA甲基化和核苷酸合成所需的两种维生素，因此也会影响细胞的完整性。尽管大量饮酒对叶酸和维生素B（12）状态的影响已得到充分文献证明，但很少有研究针对在受控环境中摄入适量酒精的影响。目的：本研究旨在确定适度饮酒对健康，营养丰富，绝经后妇女的叶酸和维生素B（12）状态的影响。设计：研究设计是一项随机，饮食控制的交叉干预。绝经后妇女（n = 53）随机接受三种8周酒精治疗：0、15和30 g /天。在治疗期之前有2-5周的清除期。在基线和每个治疗期的第8周收集血液，分析血清叶酸，维生素B（12），高半胱氨酸（HCY）和甲基丙二酸（MMA）的浓度。结果：调整了体重指数（BMI）后，从0到30克酒精/天的平均血清维生素B（12）浓度观察到显着降低5％（461.45 +/- 30.26相对440.25 +/- 30.24 pg /ml;P=0.03）。从0到30 g酒精/天，平均血清HCY浓度倾向于增加3％（9.44 +/- 0.37 vs 9.73 +/- 0.37 micromol / l; P = 0.05）。饮酒对血清叶酸或MMA浓度无明显影响。结论：在健康，营养丰富的绝经后妇女中，适度饮酒可能会降低维生素B（12）的状态。

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