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首页> 外文期刊>European journal of pediatrics >Safety and tolerance of a new extensively hydrolyzed rice protein-based formula in the management of infants with cow's milk protein allergy
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Safety and tolerance of a new extensively hydrolyzed rice protein-based formula in the management of infants with cow's milk protein allergy

机译：一种新的广泛水解的基于大米蛋白的配方食品在对牛奶蛋白过敏婴儿的管理中的安全性和耐受性

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Guidelines recommend the use of extensively hydrolyzed cow's milk protein-based formulas (eHF) in the treatment of infants with cow's milk protein allergy (CMPA). Extensively hydrolyzed rice protein infant formula (eRHF) has recently become available and could offer a valid alternative. A prospective trial was performed to evaluate the hypo-allergenicity and safety of a new eRHF in infants with a confirmed CMPA. Patients were fed the study formula for 6 months. Clinical tolerance of the eRHF was evaluated with a symptom-based score (SBS) and growth (weight and length) was monitored. Forty infants (mean age, 3.4 months; range, 1-6 months) with CMPA confirmed by a food challenge were enrolled. All infants tolerated the eRHF and the SBS significantly decreased as of the first month of intervention. Moreover, the eRHF allowed a catch-up to normal weight gain as of the first month as well as a normalization of the weight-for-age, weight-for length, and BMI z-scores within the 6-month study period. Conclusion: In accordance with current guidelines, this eRHF was tolerated by more than 90 % of children with proven CMPA with a 95 % confidence interval. This eRHF is an adequate and safe alternative to cow milk-based eHF.
机译：指南建议使用广泛水解的基于牛乳蛋白的配方食品（eHF）治疗患有牛乳蛋白过敏（CMPA）的婴儿。广泛水解的大米蛋白婴儿配方食品（eRHF）最近可用，可以提供有效的替代方法。进行了一项前瞻性试验，以评估新的eRHF对确诊为CMPA的婴儿的低变应原性和安全性。患者接受研究配方食品喂养6个月。使用基于症状的评分（SBS）评估eRHF的临床耐受性，并监测生长（体重和身长）。入选了通过食物挑战证实患有CMPA的40例婴儿（平均年龄3.4个月;范围1-6个月）。干预的第一个月，所有婴儿均耐受eRHF和SBS显着下降。此外，eRHF允许在第一个月内追赶正常的体重增长，并在六个月的研究期内使年龄体重，体重长度和BMI z得分正常化。结论：按照现行指南，超过90％的经证实CMPA的儿童可耐受eRHF，置信区间为95％。该eRHF是基于牛奶的eHF的适当且安全的替代品。

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