...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>European journal of paediatric neurology: EJPN : official journal of the European Paediatric Neurology Society >'MR spectroscopy differentiation between high and low grade astrocytomas: a comparison between paediatric and adult tumours'.
【24h】

'MR spectroscopy differentiation between high and low grade astrocytomas: a comparison between paediatric and adult tumours'.

机译：``高，低度星形细胞瘤的MR光谱鉴别：小儿和成人肿瘤的比较''。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: To investigate whether pathologically similar astrocytomas in adults and children may also show metabolic similarities in proton magnetic resonance spectroscopy ((1)H-MRS) and whether the MRS data could help to differentiate between low and high grade gliomas for the different groups. MATERIAL AND METHODS: Twelve children (5 WHO II astrocytomas, 7 WHO III astrocytomas) and 37 adults (21 WHO II astrocytomas, 16 WHO III astrocytomas) were included in this study. MR spectroscopic data were evaluated retrospectively using normalized measures of total choline (tCho), N-acetyl-aspartate (NAA) and total creatine (tCr). These metabolites were used to differentiate between WHO II and WHO III astrocytomas in children and adults. Histopathological grading was performed using WHO criteria. (1)H-MRS was carried out prior to the commencement of any treatment. Signal intensities of tCho, NAA and tCr were normalized to their values in contralateral brain tissue. The resulting concentration ratios were then used to calculate the change in the intratumoural ratio of NAA to tCho. A Mann-Whitney U-Test was performed to evaluate differences within the respective groups. RESULTS: In both groups, loss of NAA and increase of tCho were more pronounced in WHO III than in WHO II astrocytoma. The best discriminator to differentiate between low and high grade gliomas was found to be the ratio of NAA/tCho (p < 0.01). CONCLUSION: The normalized metabolite signal intensities ratio NAA to tCho is the most accurate in differentiating between low and high grade astrocytomas in both children and adults.
机译：目的：调查在成人和儿童中病理相似的星形细胞瘤是否也可能在质子磁共振波谱中显示出代谢相似性（（1）H-MRS），以及MRS数据是否有助于区分不同组的低度和高度神经胶质瘤。材料与方法：这项研究包括十二名儿童（5名WHO II星形细胞瘤，7名WHO III星形细胞瘤）和37名成人（21名WHO II星形细胞瘤，16名WHO III星形细胞瘤）。使用总胆碱（tCho），N-乙酰天门冬氨酸（NAA）和总肌酸（tCr）的标准化量度对MR光谱数据进行回顾性评估。这些代谢物用于区分儿童和成人的WHO II和WHO III星形细胞瘤。使用WHO标准进行组织病理学分级。 （1）H-MRS在任何治疗开始之前进行。将tCho，NAA和tCr的信号强度标准化为对侧脑组织中的值。然后将所得的浓度比用于计算NAA与tCho的肿瘤内比的变化。进行了Mann-Whitney U检验以评估各个组之间的差异。结果：在这两组中，WHO III的NAA丧失和tCho的增加比WHO II的星形细胞瘤更为明显。发现区分低度和高度神经胶质瘤的最佳区分因素是NAA / tCho的比率（p <0.01）。结论：归一化代谢物信号强度比NAA与tCho在区分儿童和成人的低度和高度星形细胞瘤方面最准确。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号