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首页> 外文期刊>European journal of paediatric neurology: EJPN : official journal of the European Paediatric Neurology Society >An association study between SNAP-25 gene and attention-deficit hyperactivity disorder.
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An association study between SNAP-25 gene and attention-deficit hyperactivity disorder.

机译：SNAP-25基因与注意力缺陷多动障碍之间的关联研究。

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摘要

Attention-Deficit Hyperactivity Disorder (ADHD) is the most common behavioral disorder in childhood. Genetic associations have been reported between ADHD and polymorphic variants within or near dopamine pathway genes. Synaptosomal-associated protein, 25 kDa (SNAP-25), a presynaptic plasma membrane protein with an integral role in synaptic transmission, has shown association with ADHD in several datasets. We characterized two single-nucleotide polymorphisms (rs362549, rs363006) and one microsatellite [5'-UTR (TAAA)(n)] of SNAP-25. The association of these variants with ADHD was assessed in 102 trios collected from 90 male and 12 female probands. Transmission disequilibrium test (TDT) analysis showed that none of the polymorphic alleles were preferentially transmitted to the probands. Quantitative analysis was also conducted to assess the relationship between these marker alleles and the severity of ADHD symptoms. Analysis of the DSM-IV subtypes indicated that a significant association was identified between SNP rs362549 and ADHD subtypes (P = 0.0047). This is the first report of an association between SNAP-25 and ADHD in Chinese subjects of Han descent. We still support the premise that SNAP-25 is a genetic susceptibility factor for ADHD.
机译：注意缺陷多动障碍（ADHD）是儿童期最常见的行为障碍。已经报道了ADHD与多巴胺途径基因内或附近的多态性变体之间的遗传关联。突触体相关蛋白25 kDa（SNAP-25）是一种突触前质膜蛋白，在突触传递中起着不可或缺的作用，在一些数据集中显示与ADHD相关。我们表征了两个单核苷酸多态性（rs362549，rs363006）和一个SNAP-25的微卫星[5'-UTR（TAAA）（n）]。从90个男性和12个女性先证者中收集了102个三重奏，评估了这些变体与ADHD的关联。传输不平衡测试（TDT）分析表明，所有多态性等位基因均未优先传输至先证者。还进行了定量分析以评估这些标记等位基因与ADHD症状严重程度之间的关系。对DSM-IV亚型的分析表明，SNP rs362549与ADHD亚型之间存在显着相关性（P = 0.0047）。这是中国汉族人群SNAP-25与ADHD之间关系的首次报道。我们仍然支持SNAP-25是ADHD的遗传易感性因素的前提。

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